Identification of Significant Pathways Induced by PAX5 Haploinsufficiency Based on Protein-Protein Interaction Networks and Cluster Analysis in Raji Cell Line
Joint Authors
Li, Tongjuan
Shang, Zhen
Gu, Jia
Zhao, Lei
Liang, Xue
Fu, Xing
Wang, Jue
Huang, Wei
Zhou, Jianfeng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
PAX5 encodes a transcription factor essential for B-cell differentiation, and PAX5 haploinsufficiency is involved in tumorigenesis.
There were few studies on how PAX5 haploinsufficiency regulated genes expression to promote tumorigenesis.
In this study, we constructed the cell model of PAX5 haploinsufficiency using gene editing technology in Raji cells, detected differentially expressed genes in PAX5 haploinsufficiency Raji cells, and used protein-protein interaction networks and cluster analysis to comprehensively investigate the cellular pathways involved in PAX5 haploinsufficiency.
The clusters of gene transcription, inflammatory and immune response, and cancer pathways were identified as three important pathways associated with PAX5 haploinsufficiency in Raji cells.
These changes hinted that the mechanism of PAX5 haploinsufficiency promoting tumorigenesis may be related to genomic instability, immune tolerance, and tumor pathways.
American Psychological Association (APA)
Gu, Jia& Li, Tongjuan& Zhao, Lei& Liang, Xue& Fu, Xing& Wang, Jue…[et al.]. 2017. Identification of Significant Pathways Induced by PAX5 Haploinsufficiency Based on Protein-Protein Interaction Networks and Cluster Analysis in Raji Cell Line. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137563
Modern Language Association (MLA)
Gu, Jia…[et al.]. Identification of Significant Pathways Induced by PAX5 Haploinsufficiency Based on Protein-Protein Interaction Networks and Cluster Analysis in Raji Cell Line. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137563
American Medical Association (AMA)
Gu, Jia& Li, Tongjuan& Zhao, Lei& Liang, Xue& Fu, Xing& Wang, Jue…[et al.]. Identification of Significant Pathways Induced by PAX5 Haploinsufficiency Based on Protein-Protein Interaction Networks and Cluster Analysis in Raji Cell Line. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137563