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CMIP Promotes Proliferation and Metastasis in Human Glioma
Joint Authors
Wang, Bin
Wu, Qiang
Wu, Zheng-Sheng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Glioma is one of the most common primary malignant brain tumors and the outcomes are generally poor.
The intrinsic mechanisms involved in glioma development and progression remain unclear.
Further studies are urgent and necessary.
In this study, we have proven that CMIP (C-Maf-inducing protein) promotes cell proliferation and metastasis in A172 cells through knockdown of CMIP and in U251 cells through overexpression of CMIP by using MTT assay, cell colony formation assay, cell migration assay, and cell invasion assay.
Furthermore, we discovered that CMIP upregulates MDM2, which is involved in the promoting role of CMIP in human glioma cells.
For clinical study, 99 glioma tissues and 59 normal tissues were analyzed.
CMIP expression was higher in glioma tissues than in normal tissues.
In glioma tissues, CMIP is found to correlate positively with tumor grade but no significant correlation is found with patients’ age, gender, or Karnofsky performance score (KPS).
Moreover, CMIP also correlates with low relapse-free survival (RFS) rate and overall survival (OS) rate in glioma patients.
Therefore, CMIP is oncogenic and could be a potential target for human glioma diagnosis and therapy.
American Psychological Association (APA)
Wang, Bin& Wu, Zheng-Sheng& Wu, Qiang. 2017. CMIP Promotes Proliferation and Metastasis in Human Glioma. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137567
Modern Language Association (MLA)
Wang, Bin…[et al.]. CMIP Promotes Proliferation and Metastasis in Human Glioma. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137567
American Medical Association (AMA)
Wang, Bin& Wu, Zheng-Sheng& Wu, Qiang. CMIP Promotes Proliferation and Metastasis in Human Glioma. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137567