Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide
Joint Authors
Nagai, Noriaki
Kotani, Sachiyo
Mano, Yu
Ueno, Akina
Ito, Yoshimasa
Kitaba, Toshio
Takata, Takumi
Fujii, Noriko
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It is well known that oxidative stresses induce the production of amyloid β (Aβ) in the brain, lens, and retina, leading to age-related diseases.
In the present study, we investigated the effects of ferulic acid on the Aβ levels in H2O2-stimulated human lens epithelial (HLE) SRA 01/04 cells.
Three types of Aβ peptides (Aβ1-40, Aβ1-42, and Aβ1-43) were measured by ELISA, and the levels of mRNA for the expressed proteins related to Aβ production (APP, BACE1, and PS proteins) and degradation (ADAM10, NEP, and ECE1 proteins) were determined by quantitative real-time RT-PCR.
H2O2 stimulation augmented gene expression of the proteins related to Aβ production, resulting in the production of three types of Aβ peptides.
Treatment with 0.1 μM ferulic acid attenuated the augmentations of gene expression and production of the proteins related to the secretion of three types of Aβ peptides in the H2O2-stimulated HLE cells.
These results provided evidence of antioxidative functions of ferulic acid for lens epithelial cells.
American Psychological Association (APA)
Nagai, Noriaki& Kotani, Sachiyo& Mano, Yu& Ueno, Akina& Ito, Yoshimasa& Kitaba, Toshio…[et al.]. 2017. Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137575
Modern Language Association (MLA)
Nagai, Noriaki…[et al.]. Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137575
American Medical Association (AMA)
Nagai, Noriaki& Kotani, Sachiyo& Mano, Yu& Ueno, Akina& Ito, Yoshimasa& Kitaba, Toshio…[et al.]. Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137575