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MicroRNA-31 Function as a Suppressor Was Regulated by Epigenetic Mechanisms in Gastric Cancer
Joint Authors
Wei, Jun
Wang, Zijian
Wang, Zhixiang
Yang, Yong
Fu, Changlai
Zhu, Jianqing
Jiang, Danbin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Gastric cancer is one of the most lethal malignancies worldwide.
The aberrant expression of microRNA-31 (miR-31) has been reported in gastric cancer; however, its regulation mechanisms are still unclear.
Here, we confirmed that miR-31 expression was significantly decreased in gastric cancer tissue and cell lines.
Ectopic expression of miR-31 potentially suppresses proliferation and induced early apoptosis in gastric cancer cells.
Furthermore, miR-31 expression was regulated as a result of epigenetic mechanisms.
The downregulation of miR-31 was associated with promoter DNA methylation status in gastric cancer and cell lines.
Moreover, we found that HDAC2 was the direct target of miR-31 by binding to 3′-UTR from the results of luciferase reporter assays, qRT-PCR, and western blotting.
HDAC2 played an activation role in tumor growth, whose expression is upregulated and inversely associated with miR-31 levels.
All the results suggested that miR-31 function as a crucial tumor suppressor was regulated by epigenetic mechanisms in gastric cancer.
We found an epigenetic pathway loop, DNA methylation-miRNA expression-target gene-tumor progression in gastric cancer, and also provided implications for molecular diagnosis and therapeutics of gastric malignancies by detecting miR-31 as a potential target.
American Psychological Association (APA)
Wei, Jun& Wang, Zijian& Wang, Zhixiang& Yang, Yong& Fu, Changlai& Zhu, Jianqing…[et al.]. 2017. MicroRNA-31 Function as a Suppressor Was Regulated by Epigenetic Mechanisms in Gastric Cancer. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137581
Modern Language Association (MLA)
Wei, Jun…[et al.]. MicroRNA-31 Function as a Suppressor Was Regulated by Epigenetic Mechanisms in Gastric Cancer. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1137581
American Medical Association (AMA)
Wei, Jun& Wang, Zijian& Wang, Zhixiang& Yang, Yong& Fu, Changlai& Zhu, Jianqing…[et al.]. MicroRNA-31 Function as a Suppressor Was Regulated by Epigenetic Mechanisms in Gastric Cancer. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137581