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CD36 Gene Polymorphisms Are Associated with Intracerebral Hemorrhage Susceptibility in a Han Chinese Population
Joint Authors
Gong, Qiu-Wen
Liao, Mao-Fan
Liu, Liang
Xiong, Xiao-Yi
Zhang, Qin
Zhong, Qi
Zhou, Kai
Yang, Yuan-Rui
Meng, Zhao-You
Gong, Chang-Xiong
Xu, Rui
Yang, Qing-Wu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The CD36 gene encodes a membrane glycoprotein (type B scavenger receptor, SR-B2) that plays a crucial role in lipid sensing, innate immunity, atherogenesis, and glycolipid metabolism.
In this study, we aimed to investigate the association between CD36 gene polymorphisms and intracerebral hemorrhage (ICH) in a Han Chinese population.
We performed genotype and allele analyses for eleven single nucleotide polymorphisms (SNPs) of CD36 in a case-controlled study involving 292 ICH patients and 298 control participants.
Eleven SNPs were genotyped by the Improved Multiple Ligase Detection Reaction (iMLDR) method.
The results indicated that the SNP rs1194182 values were significantly different between ICH group and control group in a dominant model after adjusting for confounding factors.
The subgroup analysis conducted for rs1194182 showed that the allele G frequencies were significantly different between ICH patients and controls in hypertension group via a dominant model.
We then analyzed the rs1194182 genotype distributions among different groups of the serum lipid groups, including BMI, TC, TG, HDL, and LDL.
However, no significant differences were found in the analysis of other subgroups.
Taken together, these findings indicate that rs1194182 polymorphism in the CD36 gene was associated with ICH, and genotype GG could be an independent predictor.
American Psychological Association (APA)
Gong, Qiu-Wen& Liao, Mao-Fan& Liu, Liang& Xiong, Xiao-Yi& Zhang, Qin& Zhong, Qi…[et al.]. 2017. CD36 Gene Polymorphisms Are Associated with Intracerebral Hemorrhage Susceptibility in a Han Chinese Population. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137590
Modern Language Association (MLA)
Gong, Qiu-Wen…[et al.]. CD36 Gene Polymorphisms Are Associated with Intracerebral Hemorrhage Susceptibility in a Han Chinese Population. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1137590
American Medical Association (AMA)
Gong, Qiu-Wen& Liao, Mao-Fan& Liu, Liang& Xiong, Xiao-Yi& Zhang, Qin& Zhong, Qi…[et al.]. CD36 Gene Polymorphisms Are Associated with Intracerebral Hemorrhage Susceptibility in a Han Chinese Population. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137590