![](/images/graphics-bg.png)
Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach
Joint Authors
Srinivasan, Ramalingam
Aruna, Arumugam
Lee, Jong Suk
Kim, Myunghee
Shivakumar, Muthugounder Subramaniam
Natarajan, D.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present study aimed to evaluate the antioxidant and antiproliferative potential of ursolic acid and thujone isolated from leaves of Elaeagnus indica and Memecylon edule and their inhibitory effect on topoisomerase II using molecular docking study.
The isolated ursolic acid and thujone were examined for different types of free radicals scavenging activity, the antiproliferative potential on U-937 and HT-60 cell lines by adopting standard methods.
Further, these compounds were docked with the active site of the ATPase region of topoisomerase II.
The findings of the research revealed that ursolic acid harbor strong antioxidant and antiproliferative capacity with low IC50 values than the thujone in all tested methods.
Moreover, ursolic acid shows significant inhibition effect on topoisomerase II with a considerable docking score (−8.0312) and GLIDE energy (−51.86 kca/mol).
The present outcome concludes that ursolic acid possesses significant antioxidant and antiproliferative potential, which can be used in the development of novel antioxidant and antiproliferative agents in the future.
American Psychological Association (APA)
Srinivasan, Ramalingam& Aruna, Arumugam& Lee, Jong Suk& Kim, Myunghee& Shivakumar, Muthugounder Subramaniam& Natarajan, D.. 2020. Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137605
Modern Language Association (MLA)
Srinivasan, Ramalingam…[et al.]. Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1137605
American Medical Association (AMA)
Srinivasan, Ramalingam& Aruna, Arumugam& Lee, Jong Suk& Kim, Myunghee& Shivakumar, Muthugounder Subramaniam& Natarajan, D.. Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137605