The Distribution of Phosphatidylcholine Species in Superficial-Type Pharyngeal Carcinoma
Joint Authors
Ishikawa, Seiji
Morita, Shuko
Hirano, Shigeru
Kitamura, Morimasa
Muto, Manabu
Hayasaka, Takahiro
Shinriki, Satoru
Masaki, Noritaka
Setou, Mitsutoshi
Ito, Juichi
Tateya, Ichiro
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
Superficial-type pharyngeal squamous cell carcinoma (STPSCC) is defined as carcinoma in situ or microinvasive squamous cell carcinoma without invasion to the muscular layer.
An exploration of the biological characteristics of STPSCC could uncover the invasion mechanism of this carcinoma.
Phosphatidylcholine (PC) in combination with fatty acids is considered to play an important role in cell motility.
Imaging mass spectrometry (IMS) is especially suitable for phospholipid analysis because this technique can distinguish even fatty acid compositions.
Study Design.
IMS analysis of frozen human specimens.
Methods.
IMS analysis was conducted to elucidate the distribution of PC species in STPSCC tissues.
STPSCC tissue sections from five patients were analyzed, and we identified the signals that showed significant increases in the subepithelial invasive region relative to the superficial region.
Results.
Three kinds of PC species containing arachidonic acid, that is, PC (16:0/20:4), PC (18:1/20:4), and PC (18:0/20:4), were increased in the subepithelial invasive region.
Conclusion.
These results may be associated with the invasion mechanism of hypopharyngeal carcinoma.
American Psychological Association (APA)
Ishikawa, Seiji& Tateya, Ichiro& Hayasaka, Takahiro& Shinriki, Satoru& Masaki, Noritaka& Hirano, Shigeru…[et al.]. 2017. The Distribution of Phosphatidylcholine Species in Superficial-Type Pharyngeal Carcinoma. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137608
Modern Language Association (MLA)
Ishikawa, Seiji…[et al.]. The Distribution of Phosphatidylcholine Species in Superficial-Type Pharyngeal Carcinoma. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1137608
American Medical Association (AMA)
Ishikawa, Seiji& Tateya, Ichiro& Hayasaka, Takahiro& Shinriki, Satoru& Masaki, Noritaka& Hirano, Shigeru…[et al.]. The Distribution of Phosphatidylcholine Species in Superficial-Type Pharyngeal Carcinoma. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137608