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Imaging of Myocardial Fibrosis in Patients with End-Stage Renal Disease: Current Limitations and Future Possibilities
Joint Authors
Graham-Brown, M. P. M.
Patel, A. S.
March, D. S.
Marsh, A.-M.
McAdam, J.
McCann, G. P.
Burton, J. O.
Stensel, David John
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cardiovascular disease in patients with end-stage renal disease (ESRD) is driven by a different set of processes than in the general population.
These processes lead to pathological changes in cardiac structure and function that include the development of left ventricular hypertrophy and left ventricular dilatation and the development of myocardial fibrosis.
Reduction in left ventricular hypertrophy has been the established goal of many interventional trials in patients with chronic kidney disease, but a recent systematic review has questioned whether reduction of left ventricular hypertrophy improves cardiovascular mortality as previously thought.
The development of novel imaging biomarkers that link to cardiovascular outcomes and that are specific to the disease processes in ESRD is therefore required.
Postmortem studies of patients with ESRD on hemodialysis have shown that the extent of myocardial fibrosis is strongly linked to cardiovascular death and accurate imaging of myocardial fibrosis would be an attractive target as an imaging biomarker.
In this article we will discuss the current imaging methods available to measure myocardial fibrosis in patients with ESRD, the reliability of the techniques, specific challenges and important limitations in patients with ESRD, and how to further develop the techniques we have so they are sufficiently robust for use in future clinical trials.
American Psychological Association (APA)
Graham-Brown, M. P. M.& Patel, A. S.& Stensel, David John& March, D. S.& Marsh, A.-M.& McAdam, J.…[et al.]. 2017. Imaging of Myocardial Fibrosis in Patients with End-Stage Renal Disease: Current Limitations and Future Possibilities. BioMed Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1137636
Modern Language Association (MLA)
Graham-Brown, M. P. M.…[et al.]. Imaging of Myocardial Fibrosis in Patients with End-Stage Renal Disease: Current Limitations and Future Possibilities. BioMed Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1137636
American Medical Association (AMA)
Graham-Brown, M. P. M.& Patel, A. S.& Stensel, David John& March, D. S.& Marsh, A.-M.& McAdam, J.…[et al.]. Imaging of Myocardial Fibrosis in Patients with End-Stage Renal Disease: Current Limitations and Future Possibilities. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1137636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137636