High Expression of Both Resistin and Fascin-1 Predicts a Poor Prognosis in Patients with Colorectal Cancer
Joint Authors
Tang, Chih-Hsin
Wang, Chao-Qun
Wang, Yan
Huang, Bi-Fei
Du, Zhang
Zeng, Yue
Wang, Qian
Shao, Jun-Kang
Jin, Lu-Lu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Emerging evidence indicates that resistin and fascin-1 may possess a causal role in the development of several types of cancers.
However, the clinical significance of resistin expression in colorectal cancer (CRC) tissues is unclear, and there are no reports of any correlation between resistin and fascin-1.
Our analyses explored the expression of resistin in CRC tissue and analyzed the clinical and prognostic significance of the observed positive correlation between resistin and fascin-1.
The rate of strongly positive resistin expression (27.5%) was significantly higher in CRC tissues than in normal colorectal tissues (5.2%).
Strongly positive resistin expression is related to multiple poor prognostic factors in CRC, including depth of tumor invasion, lymph node metastasis, and tumor stage.
In this study, survival was worse in CRC patients with high levels of both resistin and fascin-1 expression than in those with high levels of only one protein or normal levels of both proteins.
We suggest that a combined high level of resistin and fascin-1 expression correlates reliably with survival in CRC, so it may serve as a potential therapeutic target.
American Psychological Association (APA)
Wang, Chao-Qun& Wang, Yan& Huang, Bi-Fei& Tang, Chih-Hsin& Du, Zhang& Zeng, Yue…[et al.]. 2020. High Expression of Both Resistin and Fascin-1 Predicts a Poor Prognosis in Patients with Colorectal Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1137638
Modern Language Association (MLA)
Wang, Chao-Qun…[et al.]. High Expression of Both Resistin and Fascin-1 Predicts a Poor Prognosis in Patients with Colorectal Cancer. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1137638
American Medical Association (AMA)
Wang, Chao-Qun& Wang, Yan& Huang, Bi-Fei& Tang, Chih-Hsin& Du, Zhang& Zeng, Yue…[et al.]. High Expression of Both Resistin and Fascin-1 Predicts a Poor Prognosis in Patients with Colorectal Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1137638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137638