Genetic Variations in miR-30 Family Member Regulatory Regions Are Associated with Breast Cancer Risk in a Chinese Population

Joint Authors

Chen, Jiaping
Jiang, Yue
Jin, Guangfu
Ma, Hongxia
Hu, Zhibin
Shen, Hongbing
Dai, Juncheng
Wang, Lijuan
Zhou, Jing
Liu, Sijun
Zhou, Wen
Du, Jiangbo

Source

BioMed Research International

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-03-27

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

MicroRNAs (miRNAs) of the miR-30 family are closely linked with tumor metastasis and play key roles in the complex malignant phenotypes of cancers by targeting many tumor-related genes.

Deregulated expression of miR-30 family members has been commonly observed in breast cancer.

However, associations between the genetic variants in the regulatory region of miR-30 family and the risk of breast cancer are still limited, especially in the Chinese Han population.

In the present study, we conducted a case-control analysis wherein 1064 breast cancer patients and 1073 healthy controls underwent genotyping of 10 SNPs in the regulatory region of miR-30 family members.

Multivariate logistic regression analyses illustrated that the rs763354 variant in the miR-30a regulatory region was linked with a significant decrease in breast cancer risk in an additive model (adjusted OR=0.86, 95% CI: 0.75-0.98, P=0.022).

Further, eQTL analyses also indicated that this SNP was associated with miR-30a expression levels in breast cancer samples compiled in the TCGA database (P=0.020).

The Kaplan-Meier plotter showed that breast cancer patients with higher miR-30a expression have significantly better outcomes than do patients expressing low levels of this miRNA (HR=0.75, 95% CI: 0.61-0.91, P=0.0041).

Together, these findings suggest that the miR-30a rs763354 SNP is an important regulator of breast cancer risk, thus making it a potentially viable prognostic biomarker and one that can be used to guide therapeutic treatment in affected patients.

American Psychological Association (APA)

Zhou, Jing& Wang, Lijuan& Liu, Sijun& Zhou, Wen& Jiang, Yue& Du, Jiangbo…[et al.]. 2020. Genetic Variations in miR-30 Family Member Regulatory Regions Are Associated with Breast Cancer Risk in a Chinese Population. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137652

Modern Language Association (MLA)

Zhou, Jing…[et al.]. Genetic Variations in miR-30 Family Member Regulatory Regions Are Associated with Breast Cancer Risk in a Chinese Population. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1137652

American Medical Association (AMA)

Zhou, Jing& Wang, Lijuan& Liu, Sijun& Zhou, Wen& Jiang, Yue& Du, Jiangbo…[et al.]. Genetic Variations in miR-30 Family Member Regulatory Regions Are Associated with Breast Cancer Risk in a Chinese Population. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137652

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1137652