Genetic Variations in miR-30 Family Member Regulatory Regions Are Associated with Breast Cancer Risk in a Chinese Population
Joint Authors
Chen, Jiaping
Jiang, Yue
Jin, Guangfu
Ma, Hongxia
Hu, Zhibin
Shen, Hongbing
Dai, Juncheng
Wang, Lijuan
Zhou, Jing
Liu, Sijun
Zhou, Wen
Du, Jiangbo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
MicroRNAs (miRNAs) of the miR-30 family are closely linked with tumor metastasis and play key roles in the complex malignant phenotypes of cancers by targeting many tumor-related genes.
Deregulated expression of miR-30 family members has been commonly observed in breast cancer.
However, associations between the genetic variants in the regulatory region of miR-30 family and the risk of breast cancer are still limited, especially in the Chinese Han population.
In the present study, we conducted a case-control analysis wherein 1064 breast cancer patients and 1073 healthy controls underwent genotyping of 10 SNPs in the regulatory region of miR-30 family members.
Multivariate logistic regression analyses illustrated that the rs763354 variant in the miR-30a regulatory region was linked with a significant decrease in breast cancer risk in an additive model (adjusted OR=0.86, 95% CI: 0.75-0.98, P=0.022).
Further, eQTL analyses also indicated that this SNP was associated with miR-30a expression levels in breast cancer samples compiled in the TCGA database (P=0.020).
The Kaplan-Meier plotter showed that breast cancer patients with higher miR-30a expression have significantly better outcomes than do patients expressing low levels of this miRNA (HR=0.75, 95% CI: 0.61-0.91, P=0.0041).
Together, these findings suggest that the miR-30a rs763354 SNP is an important regulator of breast cancer risk, thus making it a potentially viable prognostic biomarker and one that can be used to guide therapeutic treatment in affected patients.
American Psychological Association (APA)
Zhou, Jing& Wang, Lijuan& Liu, Sijun& Zhou, Wen& Jiang, Yue& Du, Jiangbo…[et al.]. 2020. Genetic Variations in miR-30 Family Member Regulatory Regions Are Associated with Breast Cancer Risk in a Chinese Population. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137652
Modern Language Association (MLA)
Zhou, Jing…[et al.]. Genetic Variations in miR-30 Family Member Regulatory Regions Are Associated with Breast Cancer Risk in a Chinese Population. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1137652
American Medical Association (AMA)
Zhou, Jing& Wang, Lijuan& Liu, Sijun& Zhou, Wen& Jiang, Yue& Du, Jiangbo…[et al.]. Genetic Variations in miR-30 Family Member Regulatory Regions Are Associated with Breast Cancer Risk in a Chinese Population. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137652
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137652