Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis
Joint Authors
Laurent, Sophie
Talla, Emmanuel
Fokam Tagne, Michel Archange
Sokeng, Sélestin Dongmo
Sakava, Paul
Henoumont, Celine
Mbafor, Joseph Tanyi
Tchuenguem Fohouo, Fernand-Nestor
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inflammatory diseases are a real public health problem worldwide.
Many synthetic drugs used in the treatment of inflammatory diseases such as steroidal anti-inflammatory drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and immunosuppressive drugs have harmful side effects.
However, there are natural products like propolis, which is traditionally used in the treatment of pain.
The objective of this work was to evaluate the anti-inflammatory and analgesic activities of the ethyl ester of arachic acid, a compound isolated from Cameroonian propolis.
The ethyl ester of arachic acid was isolated by chromatography of the ethanolic extract of propolis harvested at Tala-Mokolo (Far North Region of Cameroon) and identified by nuclear magnetic resonance (NMR) spectra and the 1H-1H correlated spectroscopy.
The anti-inflammatory and analgesic properties of oral administration of arachic acid ethyl ester (12.5, 25.0, and 50.0 mg/kg bw) were evaluated using carrageenan-induced paw edema, xylene-induced ear edema, cotton pellets-induced granuloma formation, and hot plate test in rat.
Arachic acid ethyl ester produced maximum inhibition at 50.0 mg/kg for carrageenan-induced paw edema (62.5%), xylene-induced ear edema (54.5%), cotton pellet-induced granuloma (47.4%), and increased mean latency for hot plate test in rats.
These results show clearly that the arachic acid ethyl ester has acute and chronic anti-inflammatory properties as well as central analgesic properties.
This justifies the use of propolis in the treatment of pain in traditional medicine.
American Psychological Association (APA)
Sokeng, Sélestin Dongmo& Talla, Emmanuel& Sakava, Paul& Fokam Tagne, Michel Archange& Henoumont, Celine& Laurent, Sophie…[et al.]. 2020. Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137661
Modern Language Association (MLA)
Sokeng, Sélestin Dongmo…[et al.]. Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1137661
American Medical Association (AMA)
Sokeng, Sélestin Dongmo& Talla, Emmanuel& Sakava, Paul& Fokam Tagne, Michel Archange& Henoumont, Celine& Laurent, Sophie…[et al.]. Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137661