Antineoplastic Effects of Honokiol on Melanoma
Joint Authors
Guillermo-Lagae, Ruth
Santha, Sreevidya
Thomas, Milton
Zoelle, Emily
Stevens, Jonathan
Kaushik, Radhey S.
Dwivedi, Chandradhar
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Honokiol, a plant lignan has been shown to have antineoplastic effects against nonmelanoma skin cancer developments in mice.
In this study, antineoplastic effects of honokiol were investigated in malignant melanoma models.
In vitro effects of honokiol treatment on SKMEL-2 and UACC-62 melanoma cells were evaluated by measuring the cell viability, proliferation, apoptosis, cell cycle analysis, and expressions of various proteins associated with cell cycle progression and apoptosis.
For the in vivo study, male nude mice inoculated with SKMEL-2 or UACC-62 cells received injections of sesame oil or honokiol for two to seven weeks.
In vitro honokiol treatment caused significant decrease in cell viability, proliferation, cell cycle arrest, increased apoptosis, and modulation of apoptotic and cell cycle regulatory proteins.
Honokiol caused an accumulation of cells in the G2/M phase of the cell cycle in SKMEL-2 and G0/G1 phase in UACC-62 cells.
An elevated level of caspases and PARP were observed in both cell lines treated with honokiol.
A decrease in the expression of various cell cycle regulatory proteins was also observed in honokiol treated cells.
Honokiol caused a significant reduction of tumor growth in SKMEL-2 and UACC-62 melanoma xenografts.
These findings suggest that honokiol is a good candidate for further studies as a possible treatment for malignant melanoma.
American Psychological Association (APA)
Guillermo-Lagae, Ruth& Santha, Sreevidya& Thomas, Milton& Zoelle, Emily& Stevens, Jonathan& Kaushik, Radhey S.…[et al.]. 2017. Antineoplastic Effects of Honokiol on Melanoma. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137667
Modern Language Association (MLA)
Guillermo-Lagae, Ruth…[et al.]. Antineoplastic Effects of Honokiol on Melanoma. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1137667
American Medical Association (AMA)
Guillermo-Lagae, Ruth& Santha, Sreevidya& Thomas, Milton& Zoelle, Emily& Stevens, Jonathan& Kaushik, Radhey S.…[et al.]. Antineoplastic Effects of Honokiol on Melanoma. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137667