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Downregulated METTL14 Expression Correlates with Breast Cancer Tumor Grade and Molecular Classification
Joint Authors
Wang, Qian
Huang, Bi-Fei
Shao, Jun-Kang
Dong, Xiao-Fang
Hu, Gui-Nv
Tang, Chih-Hsin
Wang, Chao-Qun
Wang, Yan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
It is unclear whether the methyltransferase-like 14 (METTL14) protein promotes or suppresses cancer growth.
We examined the association between METTL14 expression, cancer progression, and patient prognosis in a total of 398 breast cancer tissue specimens.
Significantly fewer cancer tissue specimens compared with normal breast tissue expressed high levels of METTL14 (52.8% vs.
75.0%).
METTL14 expression was negatively associated with tumor grade and positively associated with patient age, estrogen, and progesterone receptor status.
High METTL14 expression was more common in luminal A and luminal B tissue (75.9% and 60.8%, respectively), compared with human epidermal growth factor receptor 2- (HER2-) enriched and triple-negative breast cancer (TNBC) samples (38.2% and 18.6%, respectively).
In multiple logistic regression analysis, independent predictors of METTL14 expression in breast cancer included higher tumor grade (odds ratio OR=0.494, 95% confidence interval (CI): 0.289–0.844; P=0.010), TNBC subtype (OR=0.109, 95% CI: 0.054–0.222; P<0.001), and HER2-enriched subtype (OR=0.298, 95% CI: 0.156–0.567; P<0.001).
No clear relationship was observed between patient prognosis and METTL14 expression.
It appears that downregulated METTL14 expression in breast cancer is associated with tumor grade and molecular classification.
American Psychological Association (APA)
Dong, Xiao-Fang& Wang, Yan& Huang, Bi-Fei& Hu, Gui-Nv& Shao, Jun-Kang& Wang, Qian…[et al.]. 2020. Downregulated METTL14 Expression Correlates with Breast Cancer Tumor Grade and Molecular Classification. BioMed Research International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1137695
Modern Language Association (MLA)
Dong, Xiao-Fang…[et al.]. Downregulated METTL14 Expression Correlates with Breast Cancer Tumor Grade and Molecular Classification. BioMed Research International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1137695
American Medical Association (AMA)
Dong, Xiao-Fang& Wang, Yan& Huang, Bi-Fei& Hu, Gui-Nv& Shao, Jun-Kang& Wang, Qian…[et al.]. Downregulated METTL14 Expression Correlates with Breast Cancer Tumor Grade and Molecular Classification. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1137695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137695