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Effect of Prior Atorvastatin Treatment on the Frequency of Hospital Acquired Pneumonia and Evolution of Biomarkers in Patients with Acute Ischemic Stroke: A Multicenter Prospective Study
Joint Authors
Zhu, Cheng
Yu, Yuetian
Gao, Yuan
Liu, Chunyan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To investigate whether prior treatment of atorvastatin reduces the frequency of hospital acquired pneumonia (HAP).
Methods.
Totally, 492 patients with acute ischemic stroke and Glasgow Coma Scale ≤ 8 were enrolled in this study.
Subjects were assigned to prior atorvastatin treatment group (n=268, PG) and no prior treatment group (n=224, NG).
All the patients were given 20 mg atorvastatin every night during their hospital stay.
HAP frequency and 28-day mortality were measured.
Levels of inflammatory biomarkers [white blood cell (WBC), procalcitonin (PCT), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6)] were tested.
Results.
There was no significant difference in the incidence of HAP between PG and NG (25.74% versus.
24.55%, p>0.05) and 28-day mortality (50.72% versus 58.18%, p>0.05).
However, prior statin treatment did modify the mortality of ventilator associated pneumonia (VAP) (36.54% versus 58.14%, p=0.041) and proved to be a protective factor (HR, 0.564; 95% CI, 0.310~0.825, p=0.038).
Concentrations of TNF-α and IL-6 in PG VAP cases were lower than those in NG VAP cases (p<0.01).
Conclusions.
Prior atorvastatin treatment in patients with ischemic stroke was associated with a lower concentration of IL-6 and TNF-α and improved the outcome of VAP.
This clinical study has been registered with ChiCTR-ROC-17010633 in Chinese Clinical Trial Registry.
American Psychological Association (APA)
Yu, Yuetian& Zhu, Cheng& Liu, Chunyan& Gao, Yuan. 2017. Effect of Prior Atorvastatin Treatment on the Frequency of Hospital Acquired Pneumonia and Evolution of Biomarkers in Patients with Acute Ischemic Stroke: A Multicenter Prospective Study. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137697
Modern Language Association (MLA)
Yu, Yuetian…[et al.]. Effect of Prior Atorvastatin Treatment on the Frequency of Hospital Acquired Pneumonia and Evolution of Biomarkers in Patients with Acute Ischemic Stroke: A Multicenter Prospective Study. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137697
American Medical Association (AMA)
Yu, Yuetian& Zhu, Cheng& Liu, Chunyan& Gao, Yuan. Effect of Prior Atorvastatin Treatment on the Frequency of Hospital Acquired Pneumonia and Evolution of Biomarkers in Patients with Acute Ischemic Stroke: A Multicenter Prospective Study. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137697