Effects of Rhein on Bile Acid Homeostasis in Rats
Joint Authors
Zhang, Yushi
Liu, Suyan
Meng, Jing
Xian, Zhong
Tian, Jingzhuo
Wang, Lianmei
Han, Jiayin
Deng, Nuo
Li, Chunyin
Yi, Yan
Wang, Dunfang
Liang, Aihua
Zhao, Yong
Pan, Chen
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Rhein, the active ingredient of rhubarb, a medicinal and edible plant, is widely used in clinical practice.
However, the effects of repeated intake of rhein on liver function and bile acid metabolism are rarely reported.
In this work, we investigated the alterations of 14 bile acids and hepatic transporters after rats were administered with rhein for 5 weeks.
There was no obvious injury to the liver and kidney, and there were no significant changes in biochemical indicators.
However, 1,000 mg/kg rhein increased the liver total bile acid (TBA) levels, especially taurine-conjugated bile acids (t-CBAs), inhibited the expression of farnesoid X receptor (FXR), small heterodimer partner (SHP), and bile salt export pump (BSEP) mRNA, and upregulated the expression of (cholesterol 7α-hydroxylase) CYP7A1 mRNA.
Rhein close to the clinical dose (10 mg/kg and 30 mg/kg) reduced the amounts of TBAs, especially unconjugated bile acids (UCBAs), and elevated the expression of FXR and multidrug resistance-associated protein 3 (Mrp3) mRNA.
These results denote that rhein is relatively safe to use at a reasonable dose and timing.
30 mg/kg rhein may promote bile acid transport and reduce bile acid accumulation by upregulating the expression of FXR mRNA and Mrp3 mRNA, potentially resulting in the decrease in serum UBCAs.
American Psychological Association (APA)
Xian, Zhong& Tian, Jingzhuo& Wang, Lianmei& Zhang, Yushi& Han, Jiayin& Deng, Nuo…[et al.]. 2020. Effects of Rhein on Bile Acid Homeostasis in Rats. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1137712
Modern Language Association (MLA)
Xian, Zhong…[et al.]. Effects of Rhein on Bile Acid Homeostasis in Rats. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1137712
American Medical Association (AMA)
Xian, Zhong& Tian, Jingzhuo& Wang, Lianmei& Zhang, Yushi& Han, Jiayin& Deng, Nuo…[et al.]. Effects of Rhein on Bile Acid Homeostasis in Rats. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1137712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137712