![](/images/graphics-bg.png)
Epigenetics and Signaling Pathways in Glaucoma
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Glaucoma is the most common cause of irreversible blindness worldwide.
This neurodegenerative disease becomes more prevalent with aging, but predisposing genetic and environmental factors also contribute to increased risk.
Emerging evidence now suggests that epigenetics may also be involved, which provides potential new therapeutic targets.
These three factors work through several pathways, including TGF-β, MAP kinase, Rho kinase, BDNF, JNK, PI-3/Akt, PTEN, Bcl-2, Caspase, and Calcium-Calpain signaling.
Together, these pathways result in the upregulation of proapoptotic gene expression, the downregulation of neuroprotective and prosurvival factors, and the generation of fibrosis at the trabecular meshwork, which may block aqueous humor drainage.
Novel therapeutic agents targeting these pathway members have shown preliminary success in animal models and even human trials, demonstrating that they may eventually be used to preserve retinal neurons and vision.
American Psychological Association (APA)
Gauthier, Angela C.& Liu, Ji. 2017. Epigenetics and Signaling Pathways in Glaucoma. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1137718
Modern Language Association (MLA)
Gauthier, Angela C.& Liu, Ji. Epigenetics and Signaling Pathways in Glaucoma. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1137718
American Medical Association (AMA)
Gauthier, Angela C.& Liu, Ji. Epigenetics and Signaling Pathways in Glaucoma. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1137718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137718