Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats
Joint Authors
Chang, Xue-ying
Cui, Lei
Wang, Xing-zhi
Zhang, Lei
Zhu, Dan
Zhou, Xiao-rong
Hao, Li-rong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
This study investigated whether quercetin could alleviate vascular calcification in experimental chronic renal failure rats induced by adenine.
Methods.
32 adult male Wistar rats were randomly divided into 4 groups fed normal diet, normal diet with quercetin supplementation (25 mg/kg·BW/d), 0.75% adenine diet, or adenine diet with quercetin supplementation.
All rats were sacrificed after 6 weeks of intervention.
Serum renal functions biomarkers and oxidative stress biomarkers were measured and status of vascular calcification in aorta was assessed.
Furthermore, the induced nitric oxide synthase (iNOS)/p38 mitogen activated protein kinase (p38MAPK) pathway was determined to explore the potential mechanism.
Results.
Adenine successfully induced renal failure and vascular calcification in rat model.
Quercetin supplementation reversed unfavorable changes of phosphorous, uric acid (UA) and creatinine levels, malonaldehyde (MDA) content, and superoxide dismutase (SOD) activity in serum and the increases of calcium and alkaline phosphatase (ALP) activity in the aorta (P<0.05) and attenuated calcification and calcium accumulation in the medial layer of vasculature in histopathology.
Western blot analysis showed that iNOS/p38MAPK pathway was normalized by the quercetin supplementation.
Conclusions.
Quercetin exerted a protective effect on vascular calcification in adenine-induced chronic renal failure rats, possibly through the modulation of oxidative stress and iNOs/p38MAPK pathway.
American Psychological Association (APA)
Chang, Xue-ying& Cui, Lei& Wang, Xing-zhi& Zhang, Lei& Zhu, Dan& Zhou, Xiao-rong…[et al.]. 2017. Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137722
Modern Language Association (MLA)
Chang, Xue-ying…[et al.]. Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1137722
American Medical Association (AMA)
Chang, Xue-ying& Cui, Lei& Wang, Xing-zhi& Zhang, Lei& Zhu, Dan& Zhou, Xiao-rong…[et al.]. Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137722