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Antiangiogenic Therapy for Diabetic Nephropathy
Joint Authors
Wada, Jun
Tanabe, Katsuyuki
Maeshima, Yohei
Sato, Yasufumi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Angiogenesis has been shown to be a potential therapeutic target for early stages of diabetic nephropathy in a number of animal experiments.
Vascular endothelial growth factor (VEGF) is the main mediator for abnormal angiogenesis in diabetic glomeruli.
Although beneficial effects of anti-VEGF antibodies have previously been demonstrated in diabetic animal experiments, recent basic and clinical evidence has revealed that the blockade of VEGF signaling resulted in proteinuria and renal thrombotic microangiopathy, suggesting the importance of maintaining normal levels of VEGF in the kidneys.
Therefore, antiangiogenic therapy for diabetic nephropathy should eliminate excessive glomerular angiogenic response without accelerating endothelial injury.
Some endogenous antiangiogenic factors such as endostatin and tumstatin inhibit overactivation of endothelial cells but do not specifically block VEGF signaling.
In addition, the novel endothelium-derived antiangiogenic factor vasohibin-1 enhances stress tolerance and survival of the endothelial cells, while inhibiting excess angiogenesis.
These factors have been demonstrated to suppress albuminuria and glomerular alterations in a diabetic mouse model.
Thus, antiangiogenic therapy with promising candidates will possibly improve renal prognosis in patients with early stages of diabetic nephropathy.
American Psychological Association (APA)
Tanabe, Katsuyuki& Maeshima, Yohei& Sato, Yasufumi& Wada, Jun. 2017. Antiangiogenic Therapy for Diabetic Nephropathy. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1137732
Modern Language Association (MLA)
Tanabe, Katsuyuki…[et al.]. Antiangiogenic Therapy for Diabetic Nephropathy. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1137732
American Medical Association (AMA)
Tanabe, Katsuyuki& Maeshima, Yohei& Sato, Yasufumi& Wada, Jun. Antiangiogenic Therapy for Diabetic Nephropathy. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1137732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137732