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lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process
Joint Authors
Li, Hongyi
Wang, Liwei
Qu, Yinyin
Shi, Chengmei
Yang, Ning
Gao, Xingyu
Ni, Cheng
Qian, Min
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-07
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Long noncoding RNAs (lncRNAs) play important roles in brain function modulation and neurodegenerative diseases.
However, whether lncRNA regulations are involved in the mechanisms of perioperative neurocognitive disorders, especially in anesthesia-related brain dysfunction, remain unknown.
Therefore, we explored the expression and regulation pattern profiles of lncRNAs in the hippocampus of aged rats after sevoflurane anesthesia.
Three lncRNAs and 772 protein-coding genes were identified by microarray analysis and evidenced by in vitro and in vivo experiments as differentially expressed.
Functional annotation and differentially expressed- (DE-) lncRNA-mRNA coexpression networks reveal that DE-lncRNAs are associated with mitochondrial dysfunction and oxidative stress, aging-related metabolism alterations, DNA damage, and apoptosis, as well as neurodegenerative features during sevoflurane anesthesia.
These results suggest that lncRNAs play roles in general anesthesia-related brain function modulation during the perioperative context and provide insights into the lncRNA-related modulation mechanisms and targets.
American Psychological Association (APA)
Qu, Yinyin& Li, Hongyi& Shi, Chengmei& Qian, Min& Yang, Ning& Wang, Liwei…[et al.]. 2020. lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1137733
Modern Language Association (MLA)
Qu, Yinyin…[et al.]. lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1137733
American Medical Association (AMA)
Qu, Yinyin& Li, Hongyi& Shi, Chengmei& Qian, Min& Yang, Ning& Wang, Liwei…[et al.]. lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1137733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137733