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Pharmacokinetic and Toxicological Evaluation of a Zinc Gluconate-Based Chemical Sterilant Using In Vitro and In Silico Approaches
Joint Authors
Alessandra Fortes Aiub, Claudia
Felzenszwalb, Israel
Araujo-Lima, Carlos F.
Nunes, Rafael J. M.
Carpes, Raphael M.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sclerosing agents as zinc gluconate-based chemical sterilants (Infertile®) are used for chemical castration.
This solution is injected into the animal testis, but there are not enough evidences of its safety profiles for the receivers.
The present work aimed to establish the pharmacokinetics and toxicological activity of Infertile, using in vitro and in silico approaches.
The evaluation at the endpoint showed effects in a dose-dependent manner.
Since necrosis is potentially carcinogenic, the possible cell death mechanism could be apoptosis.
Our data suggested that Infertile at 60 mM presented risk for animal health.
Even though Infertile is a licensed product by the Brazilian Ministry of Agriculture, Livestock and Supply, it presented a high mutagenic potential.
We suggest that the optimal dose must be less than 6 mM, once, at this concentration, no mutagenicity or genotoxicity was observed.
American Psychological Association (APA)
Araujo-Lima, Carlos F.& Nunes, Rafael J. M.& Carpes, Raphael M.& Alessandra Fortes Aiub, Claudia& Felzenszwalb, Israel. 2017. Pharmacokinetic and Toxicological Evaluation of a Zinc Gluconate-Based Chemical Sterilant Using In Vitro and In Silico Approaches. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137745
Modern Language Association (MLA)
Araujo-Lima, Carlos F.…[et al.]. Pharmacokinetic and Toxicological Evaluation of a Zinc Gluconate-Based Chemical Sterilant Using In Vitro and In Silico Approaches. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137745
American Medical Association (AMA)
Araujo-Lima, Carlos F.& Nunes, Rafael J. M.& Carpes, Raphael M.& Alessandra Fortes Aiub, Claudia& Felzenszwalb, Israel. Pharmacokinetic and Toxicological Evaluation of a Zinc Gluconate-Based Chemical Sterilant Using In Vitro and In Silico Approaches. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137745