Synthesis of L-Ascorbyl Flurbiprofenate by Lipase-Catalyzed Esterification and Transesterification Reactions
Joint Authors
Xin, Jia-ying
Sun, Li-rui
Chen, Shu-ming
Wang, Yan
Xia, Chun-gu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The synthesis of L-ascorbyl flurbiprofenate was achieved by esterification and transesterification in nonaqueous organic medium with Novozym 435 lipase as biocatalyst.
The conversion was greatly influenced by the kinds of organic solvents, speed of agitation, catalyst loading amount, reaction time, and molar ratio of acyl donor to L-ascorbic acid.
A series of solvents were investigated, and tert-butanol was found to be the most suitable from the standpoint of the substrate solubility and the conversion for both the esterification and transesterification.
When flurbiprofen was used as acyl donor, 61.0% of L-ascorbic acid was converted against 46.4% in the presence of flurbiprofen methyl ester.
The optimal conversion of L-ascorbic acid was obtained when the initial molar ratio of acyl donor to ascorbic acid was 5 : 1.
kinetics parameters were solved by Lineweaver-Burk equation under nonsubstrate inhibition condition.
Since transesterification has lower conversion, from the standpoint of productivity and the amount of steps required, esterification is a better method compared to transesterification.
American Psychological Association (APA)
Xin, Jia-ying& Sun, Li-rui& Chen, Shu-ming& Wang, Yan& Xia, Chun-gu. 2017. Synthesis of L-Ascorbyl Flurbiprofenate by Lipase-Catalyzed Esterification and Transesterification Reactions. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1137747
Modern Language Association (MLA)
Xin, Jia-ying…[et al.]. Synthesis of L-Ascorbyl Flurbiprofenate by Lipase-Catalyzed Esterification and Transesterification Reactions. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1137747
American Medical Association (AMA)
Xin, Jia-ying& Sun, Li-rui& Chen, Shu-ming& Wang, Yan& Xia, Chun-gu. Synthesis of L-Ascorbyl Flurbiprofenate by Lipase-Catalyzed Esterification and Transesterification Reactions. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1137747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137747