CYP2C19⁎2 Polymorphism in Chilean Patients with In-Stent Restenosis Development and Controls
Joint Authors
Saavedra, Nicolás
Salazar, Luis A.
Zambrano, Tomás
Ruedlinger, Jenny
Prado, Yalena
Bobadilla, Braulio
Potthoff, Marcelo
Pérez, Luis
Lanas, Fernando
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Clopidogrel is an antiplatelet drug especially used in patients undergoing percutaneous coronary interventions (PCI).
Polymorphisms within CYP2C19 can result in important interindividual variations regarding therapeutic efficacy.
Therefore, we aimed to evaluate the impact of the CYP2C19⁎2 variant (rs4244285) on in-stent restenosis occurrence in Chilean patients who underwent PCI and received clopidogrel.
A total of 77 cases with stenosis >50% in the angioplasty site (62.75 ± 9.8 years, 80.5% males) and 86 controls (65.45 ± 9.8 years, 72.1% males) were studied.
The polymorphism was genotyped using TaqMan® Drug Metabolism Genotyping Assays.
Overall, CYP2C19⁎2 allele frequency was 8.3%.
Diabetes, chronic lesions, and bare metal stents (BMS) were observed more often in cases than in controls (p = 0.05, p = 0.04, and p = 0.02, resp.).
Genotypic frequencies did not differ significantly between the groups (p = 0.15).
Nonetheless, the mutated allele was observed in a greater proportion in patients without in-stent restenosis (p = 0.055).
There was no significant association between the rs4244285 variant and the occurrence of in-stent restenosis after PCI (OR = 0.44; 95% CI: 0.19 to 1.04; p = 0.06).
In summary, no association was identified between the CYP2C19⁎2 variant and the development of coronary in-stent restenosis.
American Psychological Association (APA)
Ruedlinger, Jenny& Prado, Yalena& Zambrano, Tomás& Saavedra, Nicolás& Bobadilla, Braulio& Potthoff, Marcelo…[et al.]. 2017. CYP2C19⁎2 Polymorphism in Chilean Patients with In-Stent Restenosis Development and Controls. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1137759
Modern Language Association (MLA)
Ruedlinger, Jenny…[et al.]. CYP2C19⁎2 Polymorphism in Chilean Patients with In-Stent Restenosis Development and Controls. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1137759
American Medical Association (AMA)
Ruedlinger, Jenny& Prado, Yalena& Zambrano, Tomás& Saavedra, Nicolás& Bobadilla, Braulio& Potthoff, Marcelo…[et al.]. CYP2C19⁎2 Polymorphism in Chilean Patients with In-Stent Restenosis Development and Controls. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1137759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137759