A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature
Joint Authors
Chen, Rui
Wang, Yihua
Tang, Zhenrong
Liu, Shengchun
Wang, Yu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dermatofibrosarcoma protuberans (DFSP) is a rare low-grade fibroblastic mesenchymal tumor derived from the dermis.
The aim of this retrospective analysis was to summarize the clinicopathological data from our cases and published cases to offer more evidence for the recognition of dermatofibrosarcoma protuberans (DFSP).
A total of 6 breast DFSP patients who had received treatment in our hospital were retrospectively enrolled, and detailed clinicopathological data were gathered for analysis.
The median age was 29.5 years (ranging from 17 to 42 years).
Most cases presented a red or brown-red, mobile, well-circumscribed, protruding, breast mass (ranging from 1 to 3 cm).
For histopathology, all cases (6/6) showed a storiform pattern of spindle cells that were positive for CD34 (6/6) and Vimentin (5/6) and negative for smooth muscle actin (0/6) and S-100 protein (0/6).
The majority of patients (5/6) underwent wide local excision, with 2 cases treated with radiotherapy.
With a median follow-up of 36 months, all 6 patients survived without recurrence or metastasis.
The PubMed database was used to search for similar cases.
Eventually, 36 cases were included in this review, while cases without detailed clinical information or not reported in English were excluded from the analysis.
To summarize, DFSP of the breast is an extremely rare malignancy characterized by spindle tumor cells arranged in a storiform pattern and positivity for CD34.
The core needle biopsy is one of the crucial methods for its preoperative diagnosis.
Management of DFSP is mainly based on surgical excision.
It is prone to local recurrence, so long-term follow-up is required.
American Psychological Association (APA)
Wang, Yihua& Wang, Yu& Chen, Rui& Tang, Zhenrong& Liu, Shengchun. 2020. A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137765
Modern Language Association (MLA)
Wang, Yihua…[et al.]. A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1137765
American Medical Association (AMA)
Wang, Yihua& Wang, Yu& Chen, Rui& Tang, Zhenrong& Liu, Shengchun. A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137765