Systematic Identification of Key Functional Modules and Genes in Gastric Cancer
Joint Authors
Yang, Cheng
Wu, Rui
Sun, Jin-Yu
Zhao, Li-Li
Fan, Zhi-Ning
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-17
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Gastric cancer (GC) is associated with high incidence and mortality rates worldwide.
Differentially expressed gene (DEG) analysis and weighted gene coexpression network analysis (WGCNA) are important bioinformatic methods for screening core genes.
In our study, DEG analysis and WGCNA were combined to screen the hub genes, and pathway enrichment analyses were performed on the DEGs.
SBNO2 was identified as the hub gene based on the intersection between the DEGs and the purple module in WGCNA.
The expression and prognostic value of SBNO2 were verified in UALCAN, GEPIA2, Human Cancer Metastasis Database, Kaplan–Meier plotter, and TIMER.
We identified 1974 DEGs, and 28 modules were uncovered via WGCNA.
The purple module was identified as the hub module in WGCNA.
SBNO2 was identified as the hub gene, which was upregulated in tumour tissues.
Moreover, patients with GC and higher SBNO2 expression had worse prognoses.
In addition, SBNO2 was suggested to play an important role in immune cell infiltration.
In summary, based on DEGs and key modules related to GC, we identified SBNO2 as a hub gene, thereby offering novel insights into the development and treatment of GC.
American Psychological Association (APA)
Wu, Rui& Sun, Jin-Yu& Zhao, Li-Li& Fan, Zhi-Ning& Yang, Cheng. 2020. Systematic Identification of Key Functional Modules and Genes in Gastric Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1137768
Modern Language Association (MLA)
Wu, Rui…[et al.]. Systematic Identification of Key Functional Modules and Genes in Gastric Cancer. BioMed Research International No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1137768
American Medical Association (AMA)
Wu, Rui& Sun, Jin-Yu& Zhao, Li-Li& Fan, Zhi-Ning& Yang, Cheng. Systematic Identification of Key Functional Modules and Genes in Gastric Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1137768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137768