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Sertraline Induces Toxicity and Behavioral Alterations in Planarians
Joint Authors
Thumé, Isabela Salvador
Frizzo, Marcos E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Toxicity attributed to sertraline has been demonstrated recently in different cell types and also in some organisms.
We investigated the effect of sertraline on planarians, which are considered suitable for investigations in neurotoxicology and currently are widely used as an animal model in neuropharmacological studies.
Planarians treated with 10 µM sertraline showed a rapid reduction in their spontaneous movement until they became completely motionless and then showed a series of asynchronous paroxysms (seizures) followed by progressive tissue damage, beginning 48 h after the sertraline treatment, and died approximately 72 h later.
Our data showed that sertraline does not cause planarian death within the range of therapeutic concentrations; however, behavioral alterations were observed with concentrations that can be considered compatible with therapeutic ones, such as a significant reduction in planarian locomotory activity at 0.4 µM.
Treatment with 4 µM sertraline had a significant effect, reducing planarian locomotory activity and increasing the number of asynchronous paroxysms; both effects were significantly maintained even 24 h after the sertraline was withdrawn.
These behavioral changes observed at low micromolar concentrations suggest that sertraline might have residual biological consequences for planarians, even after it is withdrawn.
American Psychological Association (APA)
Thumé, Isabela Salvador& Frizzo, Marcos E.. 2017. Sertraline Induces Toxicity and Behavioral Alterations in Planarians. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137775
Modern Language Association (MLA)
Thumé, Isabela Salvador& Frizzo, Marcos E.. Sertraline Induces Toxicity and Behavioral Alterations in Planarians. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137775
American Medical Association (AMA)
Thumé, Isabela Salvador& Frizzo, Marcos E.. Sertraline Induces Toxicity and Behavioral Alterations in Planarians. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137775