Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells
Joint Authors
Yuan, Qin
Chen, Wei
Shen, XianMin
Zheng, YunFeng
Li, CunYu
Peng, GuoPing
Chen, Rong
Ma, Li
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cervical cancer is considered to be one of the most serious malignant tumors in women.
Natural compounds have been considered as important sources in the search for new anticancer agents.
Polygonum chinense (PC) has been used as herbal medicine and Chinese cool tea.
By activity-guided of the extracts from PC, PCwater shows good growth inhibition on SiHa cell, then by chromatographic analysis (HPLC and HPLC-MS/MS), we found twelve components, seven were phenolic compounds (PHE), two PHE named ellagic acid and corilagin were found to show strong growth inhibition effects in SiHa cell dose-dependently, while the seven phenolic compounds showed low inhibition on the common human HcerEpic cell.
Further research found ellagic acid and corilagin induced G2 phase cell cycle arrest by upregulating levels of P53, Bcl-2, caspase 3, and caspase 9, while the Bax was reduced.
These results suggested that PHE from PC might have potential anticancer effects against SiHa cells by acting through the apoptosis pathway, PHE from PC might have the potential to be used as a nutraceutical for the prevention and treatment of ovarian cancer.
American Psychological Association (APA)
Chen, Wei& Shen, XianMin& Ma, Li& Chen, Rong& Yuan, Qin& Zheng, YunFeng…[et al.]. 2020. Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137794
Modern Language Association (MLA)
Chen, Wei…[et al.]. Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1137794
American Medical Association (AMA)
Chen, Wei& Shen, XianMin& Ma, Li& Chen, Rong& Yuan, Qin& Zheng, YunFeng…[et al.]. Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137794