Development and In Vivo Characterization of Probiotic Lysate-Treated Chitosan Nanogel as a Novel Biocompatible Formulation for Wound Healing
Joint Authors
Heidari, Reza
Abootalebi, Seyedeh Narjes
Gholami, Ahmad
Ashoori, Yousef
Mohkam, Milad
Mousavi, Seyyed Mojtaba
Hashemi, Seyyed Alireza
Golkar, Nasim
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Wound healing is a physiological reaction to tissue injuries which plays a crucial role in replacing the destroyed tissues.
Probiotics produce valuable compounds that possess antibacterial and anti-inflammatory activities, immunomodulatory effects, and angiogenesis traits leading to the promotion of wound healing.
Chitosan nanostructures have versatile properties making them quickly produced into gels, scaffolds, nanoparticles, beads, and sponge structures that can be incorporated into wound healing processes.
In the current study, three formulations from nanogel consisting of probiotic supernatant (Lactobacillus reuteri, Lactobacillus fermentum, and Bacillus subtilis sp.
natto)-loaded chitosan nanogels were prepared from the culture of corresponding cultures.
The chitosan nanogels were previously characterized by Zetasizer, FTIR, and TEM.
The prepared formulations’ effectiveness and dressing activity were assessed by evaluating wound closure and histological trials in Sprague-Dawley rats.
The results indicated that all probiotic lysate formulations have advantages over the wound healing process.
However, Bacillus subtilis natto has a better wound healing quality, which is well known in pathology examination.
The favorable effects of probiotic lysate nanogels, including the reasonable wound closing rate, good wound appearance, and satisfactory histological observation via in vivo examination, suggest it as a promising nominee for wound healing purposes.
American Psychological Association (APA)
Ashoori, Yousef& Mohkam, Milad& Heidari, Reza& Abootalebi, Seyedeh Narjes& Mousavi, Seyyed Mojtaba& Hashemi, Seyyed Alireza…[et al.]. 2020. Development and In Vivo Characterization of Probiotic Lysate-Treated Chitosan Nanogel as a Novel Biocompatible Formulation for Wound Healing. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1137796
Modern Language Association (MLA)
Ashoori, Yousef…[et al.]. Development and In Vivo Characterization of Probiotic Lysate-Treated Chitosan Nanogel as a Novel Biocompatible Formulation for Wound Healing. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1137796
American Medical Association (AMA)
Ashoori, Yousef& Mohkam, Milad& Heidari, Reza& Abootalebi, Seyedeh Narjes& Mousavi, Seyyed Mojtaba& Hashemi, Seyyed Alireza…[et al.]. Development and In Vivo Characterization of Probiotic Lysate-Treated Chitosan Nanogel as a Novel Biocompatible Formulation for Wound Healing. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1137796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137796