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HIF1A (rs11549465) and AKNA (rs10817595) Gene Polymorphisms Are Associated with Primary Sjögren’s Syndrome
Joint Authors
Lima, Guadalupe
Rodríguez-Pérez, José Manuel
Fernández-Torres, Javier
Martínez-Nava, G. A.
López-Reyes, Alberto
Pérez-Hernández, Nonanzit
Hernández-Molina, Gabriela
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate the allele and genotype frequencies of polymorphic sites of HIF1A and ANKA genes in primary Sjögren’s syndrome (pSS).
Methods.
We included 110 patients with pSS and 141 ethnically matched healthy controls.
Three HIF1A gene polymorphisms (Pro582Ser, Ala588Thr, and C191T) and two AKNA gene polymorphisms (−1372C>A and Pro624Leu) were genotyped using TaqMan probes in a Real-Time PCR instrument.
Associations between pSS and genotypes, alleles, and inheritance models of the SNPs of interest were evaluated by logistic regression adjusted by age and gender.
Results.
The C/T genotype and the T allele of the HIF1A Pro582Ser polymorphism protected against pSS (OR = 0.22; 95% CI = 0.09–0.52; P<0.01; OR = 0.26; 95% CI = 0.12–0.58; P<0.01, resp.), whereas under a recessive model adjusted by age and gender, the AKNA −1372C>A polymorphism A/A genotype was associated with an increased risk of pSS (OR = 2.60; 95% CI = 1.11–6.12; P=0.03).
Conclusions.
We identified HIF1A Pro582Ser T allele and C/T genotype as well as AKNA −1372C>A polymorphism A/A genotype as genetic factors associated with pSS.
Further studies in other populations are needed to validate our findings and research is warranted in order to shed some light on their functional implications across biological pathways in this disease.
American Psychological Association (APA)
Hernández-Molina, Gabriela& Rodríguez-Pérez, José Manuel& Fernández-Torres, Javier& Lima, Guadalupe& Pérez-Hernández, Nonanzit& López-Reyes, Alberto…[et al.]. 2017. HIF1A (rs11549465) and AKNA (rs10817595) Gene Polymorphisms Are Associated with Primary Sjögren’s Syndrome. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137811
Modern Language Association (MLA)
Hernández-Molina, Gabriela…[et al.]. HIF1A (rs11549465) and AKNA (rs10817595) Gene Polymorphisms Are Associated with Primary Sjögren’s Syndrome. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137811
American Medical Association (AMA)
Hernández-Molina, Gabriela& Rodríguez-Pérez, José Manuel& Fernández-Torres, Javier& Lima, Guadalupe& Pérez-Hernández, Nonanzit& López-Reyes, Alberto…[et al.]. HIF1A (rs11549465) and AKNA (rs10817595) Gene Polymorphisms Are Associated with Primary Sjögren’s Syndrome. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137811