An Integrative Analysis Reveals the Potential Mechanism between Herbal Medicine Yinchen and Immunoregulation in Hepatocellular Carcinoma
Joint Authors
Mo, Zhuomao
Cao, Zhirui
Yu, Ling
Wang, Yongdan
Li, Pan
Lin, Youwu
Zhang, Shijun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
Abundant evidences in traditional Chinese medicine (TCM) supported the therapeutic value of herbal medicine Yinchen in hepatocellular carcinoma (HCC), but the underlying mechanism remains to be investigated.
Main Methods.
The intersection of immune gene set, module genes, HCC-associated genes, and target genes of Yinchen was employed for further analyses.
The module genes were identified by weighted gene coexpression network analysis, and the other three gene sets were obtained from public databases.
Subsequently, we further explored the clinical value and immunoregulation of the hub gene of intersection.
The relevant pathways related to hub gene expression were investigated by gene set enrichment analysis.
Finally, the interaction of active compounds and target genes was validated by molecular docking.
Key Findings.
Thirteen active compounds and 90 target genes of Yinchen were included.
After constructing the network among Yinchen, target genes, and HCC, BIRC5 was identified as the hub gene.
Significant difference was found between the high-expressed group and the low-expressed group in survival and stage.
Different immune subtypes also presented significant difference in BIRC5 expression.
Moreover, NK cell and T cell (CD4+ effector memory and CD4+ memory resting) were negatively correlated with BIRC5 expression, while CTLA4 and LAG3 were positively correlated.
The results of molecular docking further validated a good binding activity of quercetin-BIRC5 interaction.
Significance.
In summary, our research identified for the first time a novel underlying association among herbal medicine Yinchen, BIRC5, immunotherapy, and HCC.
We speculated that Yinchen may target the immune checkpoints (CTLA4 and LAG3) and activate the immune cells by suppressing BIRC5.
American Psychological Association (APA)
Mo, Zhuomao& Cao, Zhirui& Yu, Ling& Wang, Yongdan& Li, Pan& Lin, Youwu…[et al.]. 2020. An Integrative Analysis Reveals the Potential Mechanism between Herbal Medicine Yinchen and Immunoregulation in Hepatocellular Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137819
Modern Language Association (MLA)
Mo, Zhuomao…[et al.]. An Integrative Analysis Reveals the Potential Mechanism between Herbal Medicine Yinchen and Immunoregulation in Hepatocellular Carcinoma. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1137819
American Medical Association (AMA)
Mo, Zhuomao& Cao, Zhirui& Yu, Ling& Wang, Yongdan& Li, Pan& Lin, Youwu…[et al.]. An Integrative Analysis Reveals the Potential Mechanism between Herbal Medicine Yinchen and Immunoregulation in Hepatocellular Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137819