Monoclonal Antibodies Radiolabeling with Rhenium-188 for Radioimmunotherapy
Joint Authors
Boschi, A.
Uccelli, L.
Martini, Petra
Pasquali, M.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Rhenium-188, obtained from an alumina-based tungsten-188/rhenium-188 generator, is actually considered a useful candidate for labeling biomolecules such as antibodies, antibody fragments, peptides, and DNAs for radiotherapy.
There is a widespread interest in the availability of labeling procedures that allow obtaining Re188-labeled radiopharmaceuticals for various therapeutic applications, in particular for the rhenium attachment to tumor-specific monoclonal antibodies (Mo)Abs for immunotherapy.
Different approaches have been developed in order to obtain Re188-radioimmunoconjugates in high radiochemical purity starting from the generator eluted Re188ReO4-.
The aim of this paper is to provide a short overview on Re188-labeled (Mo)Abs, focusing in particular on the radiolabeling methods, quality control of radioimmunoconjugates, and their in vitro stability for radioimmunotherapy (RIT), with particular reference to the most important contributions published in literature in this topic.
American Psychological Association (APA)
Uccelli, L.& Martini, Petra& Pasquali, M.& Boschi, A.. 2017. Monoclonal Antibodies Radiolabeling with Rhenium-188 for Radioimmunotherapy. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137838
Modern Language Association (MLA)
Uccelli, L.…[et al.]. Monoclonal Antibodies Radiolabeling with Rhenium-188 for Radioimmunotherapy. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1137838
American Medical Association (AMA)
Uccelli, L.& Martini, Petra& Pasquali, M.& Boschi, A.. Monoclonal Antibodies Radiolabeling with Rhenium-188 for Radioimmunotherapy. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137838