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AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes
Joint Authors
Li, Xiaobo
Wu, Yiqi
Wang, Guangyou
Yang, Weiwei
Shan, Baocong
Zhao, Ran
Zhou, Jian
Zhang, Minghui
Qi, Xiaoyu
Wang, Tianzhen
Gong, Jinan
Zhu, Yuanyuan
Zhang, Yang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
AURKA, a cell cycle-regulated kinase, is associated with malignant transformation and progression in many cancer types.
We analyzed the expression change of AURKA in pan-cancer and its effect on the prognosis of cancer patients using the TCGA dataset.
We revealed that AURKA was extensively elevated and predicted a poor prognosis in most of the detected cancer types, with an exception in colon cancer.
AURKA was elevated in colon cancer, but the upregulation of AURKA indicated better outcomes of colon cancer patients.
Then we revealed that undermethylation of the AURKA gene and several transcription factors contributed to the upregulation of AURKA in colon cancer.
Moreover, we demonstrated that AURKA overexpression promoted the death of colon cancer cells induced by Oxaliplatin, whereas knockdown of AURKA significantly weakened the chemosensitivity of colon cancer cells to Oxaliplatin.
Mechanistically, AURKA inhibited DNA damage response by suppressing the expression of various DNA damage repair genes in a TP53-dependent manner, which can partly explain that ARUKA is associated with a beneficial outcome of colon cancer.
This study provided a possibility to use AURKA as a biomarker to predict the chemosensitivity of colon cancer to platinum in the clinic.
American Psychological Association (APA)
Shan, Baocong& Zhao, Ran& Zhou, Jian& Zhang, Minghui& Qi, Xiaoyu& Wang, Tianzhen…[et al.]. 2020. AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137857
Modern Language Association (MLA)
Shan, Baocong…[et al.]. AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1137857
American Medical Association (AMA)
Shan, Baocong& Zhao, Ran& Zhou, Jian& Zhang, Minghui& Qi, Xiaoyu& Wang, Tianzhen…[et al.]. AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137857