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Immunity Enhancement in Immunocompromised Gastrointestinal Cancer Patients with Allogeneic Umbilical Cord Blood Mononuclear Cell Transfusion
Joint Authors
Qiu, Ying
Zhao, Ruidong
Yun, Mark M.
Han, Xia
Yun, Feiyu
Liu, Bingchun
Zhou, Erxia
Ouyang, Xiaohui
Yun, Sheng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
In order to enhance the immunity of cancer patients to prevent relapse or to prolong survival time, umbilical cord blood mononuclear cells (UCMCs) were transplanted to cancer patients.
Patients and Methods.
UCMCs were transfused to 63 immunocompromised gastrointestinal cancer patients with nonmyeloablative (NMA) conditioning regimen.
Results.
The clinical study showed that the number of both T and B cells increased much more rapidly after transfusion of UCMCs than that of the control group without transplantation (p<0.01).
Proinflammation cytokines IFNγ and TNFα in serum increased to or above the normal range in 80.9% of patients at 12 weeks after UCMC transfusion.
However, they recovered to the normal range in 21.7% of patients at the same time point in the control group only.
In addition, the clinical investigation also showed that the transfusion of UCMC increased stable disease (SD) and reduced progressive disease (PD) significantly (p<0.01); however, it did not have significant effects on complete response (CR), partial response (PR), or mortality rates compared with the control group (p>0.05).
Conclusions.
UCMCs have powerful repairing effects on damaged cells and tissues and may reconstruct the impaired immunity.
Transfusion of UCMCs could reconstruct the immunity of cancer patients with immunosuppression.
American Psychological Association (APA)
Qiu, Ying& Zhao, Ruidong& Yun, Mark M.& Han, Xia& Yun, Feiyu& Liu, Bingchun…[et al.]. 2017. Immunity Enhancement in Immunocompromised Gastrointestinal Cancer Patients with Allogeneic Umbilical Cord Blood Mononuclear Cell Transfusion. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137858
Modern Language Association (MLA)
Qiu, Ying…[et al.]. Immunity Enhancement in Immunocompromised Gastrointestinal Cancer Patients with Allogeneic Umbilical Cord Blood Mononuclear Cell Transfusion. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137858
American Medical Association (AMA)
Qiu, Ying& Zhao, Ruidong& Yun, Mark M.& Han, Xia& Yun, Feiyu& Liu, Bingchun…[et al.]. Immunity Enhancement in Immunocompromised Gastrointestinal Cancer Patients with Allogeneic Umbilical Cord Blood Mononuclear Cell Transfusion. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137858