Teratogenic Effect of Usnic Acid from Cladonia substellata Vainio during Organogenesis
Joint Authors
da Silva, Nicácio Henrique
Martins, Monica C. B.
Silva, C. R.
Marinho, K. S. N.
Silva, T. D. S.
Ferreira, D. K. S.
Aguiar, G. M.
Santos, K. R. P.
Aguiar Júnior, F. C. A.
Santos, N. P. S.
Pereira, E. C.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Studies about toxicological potential of usnic acid are limited.
This way, the vast majority of data available in the literature are related only to biological activities.
This is the first study that aimed to evaluate the oral toxicity of usnic acid during the period of organogenesis.
Females rats were distributed in the control groups, treated I and II, at doses of 15 and 25 mg/kg, administered by gavage during the 6° to 15° days of pregnancy.
After 20 days the fetuses were removed and analyzed.
A reduction in weight gain during pregnancy, increased resorption, reduction in the number of viable fetuses, and their body weight were observed.
Morphological changes in the litter were visualized as exposure of the eye and atrophy of the limbs at the dose of 25 mg/kg.
Histological analysis of the liver of the fetus showed reduction in the number of megakaryocytes between experimental groups and increase in the number of hepatocytes in a dose of 25 mg/kg.
The experimental model used in this study reveals teratogenic effect of usnic acid in the period of organogenesis.
Since this achievement, the importance of evaluating the toxic effects of natural substances is imperative, in order to elucidate the care in their indication as drug.
American Psychological Association (APA)
Silva, C. R.& Marinho, K. S. N.& Silva, T. D. S.& Ferreira, D. K. S.& Aguiar, G. M.& Martins, Monica C. B.…[et al.]. 2017. Teratogenic Effect of Usnic Acid from Cladonia substellata Vainio during Organogenesis. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137861
Modern Language Association (MLA)
Silva, C. R.…[et al.]. Teratogenic Effect of Usnic Acid from Cladonia substellata Vainio during Organogenesis. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1137861
American Medical Association (AMA)
Silva, C. R.& Marinho, K. S. N.& Silva, T. D. S.& Ferreira, D. K. S.& Aguiar, G. M.& Martins, Monica C. B.…[et al.]. Teratogenic Effect of Usnic Acid from Cladonia substellata Vainio during Organogenesis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137861