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Expression Pattern of G-Protein-Coupled Estrogen Receptor in Myometrium of Uteri with and without Adenomyosis
Joint Authors
Li, Tin-Chiu
Duan, Hua
Wang, Sha
Gan, Lu
Xu, Qian
Li, Jin-Jiao
Sun, Fu-Qing
Tang, Yi-Qun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To compare the expression of G-protein-coupled estrogen receptor (GPER) in the junctional zone and outer myometrium of the proliferative and secretory phases of women with and without adenomyosis.
Methods.
A total of 76 women were included in this study, 42 with adenomyosis (proliferative phase, n=23; secretory phases, n=19) and 34 controls (proliferative phase, n=16; secretory phases, n=18).
Protein and total RNA were extracted from the junctional zone (JZ) and outer myometrium (OM).
GPER protein and mRNA expression levels were evaluated by the use of western blotting and real-time quantitative polymerase chain reaction (RT-qPCR).
Results.
The expression of GPER protein and mRNA in women with adenomyosis was significantly higher than that of control subjects, both in the junctional zone and in the outer myometrium and both in the proliferative and in the secretory phases.
Conclusion.
The significant and consistent increase in GPER expression in adenomyosis compared with control subjects, regardless of whether it was in the proliferative or secretory phases and regardless of whether it was in the JZ or OM, suggests that GPER plays an important role in the pathogenesis of the adenomyosis.
American Psychological Association (APA)
Li, Jin-Jiao& Duan, Hua& Wang, Sha& Sun, Fu-Qing& Gan, Lu& Tang, Yi-Qun…[et al.]. 2017. Expression Pattern of G-Protein-Coupled Estrogen Receptor in Myometrium of Uteri with and without Adenomyosis. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1137873
Modern Language Association (MLA)
Li, Jin-Jiao…[et al.]. Expression Pattern of G-Protein-Coupled Estrogen Receptor in Myometrium of Uteri with and without Adenomyosis. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1137873
American Medical Association (AMA)
Li, Jin-Jiao& Duan, Hua& Wang, Sha& Sun, Fu-Qing& Gan, Lu& Tang, Yi-Qun…[et al.]. Expression Pattern of G-Protein-Coupled Estrogen Receptor in Myometrium of Uteri with and without Adenomyosis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1137873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137873