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PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1RVEGFR2 Pathway in Papillary Thyroid Carcinoma
Joint Authors
Chen, Qin
Yu, Wen-Ying
Zhang, Huan-Huan
Zhang, Song-Zhao
Yu, Chen-Huan
Ying, Hua-Zhong
Fang, Jie
Wu, Fang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
PBX3 (Pre-B-cell leukemia homeobox 3) had been considered to be a multifunctional oncogene which involved in tumor growth, invasion, and metastasis in leukemia and some solid tumors.
However, the contribution of PBX3 to papillary thyroid carcinoma (PTC) remains unclear.
In this study, we found that PBX3 expression was significantly upregulated in PTC tissues compared to adjacent normal tissues, and high levels of PBX3 were correlated with tumor size, lymphatic metastasis, TMN stage, and poor prognosis of PTC patients.
Overexpression of PBX3 in PTC cell lines promoted cell proliferation.
Consistently, knockdown of PBX3 by shRNA induced cell cycle arrest at G0/G1 phase, and inhibited angiogenesis and tumor growth in vitro and in vivo.
Furthermore, PBX3 promoted PTC cell proliferation and angiogenesis through activation of AT1R/VEGFR2 pathway while overexpression of AT1R and treatment with VEGFA reversed PBX3-shRNA-induced decreased phosphorylation of VEGFR2 and its downstream (ERK1/2, AKT and Src).
It demonstrated that PBX3 could be used as a potential prognostic biomarker and therapeutic target for PTC.
American Psychological Association (APA)
Chen, Qin& Yu, Wen-Ying& Zhang, Huan-Huan& Zhang, Song-Zhao& Fang, Jie& Wu, Fang…[et al.]. 2020. PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1RVEGFR2 Pathway in Papillary Thyroid Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137880
Modern Language Association (MLA)
Chen, Qin…[et al.]. PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1RVEGFR2 Pathway in Papillary Thyroid Carcinoma. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1137880
American Medical Association (AMA)
Chen, Qin& Yu, Wen-Ying& Zhang, Huan-Huan& Zhang, Song-Zhao& Fang, Jie& Wu, Fang…[et al.]. PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1RVEGFR2 Pathway in Papillary Thyroid Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137880