Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis
Joint Authors
Wang, Zengjun
Zhang, Jianzhong
Xu, Aiming
Miao, Chenkui
Liu, Shouyong
Liang, Chao
Zhao, Kai
Zhu, Jundong
Hua, Yibo
Tian, Ye
Zhang, Chao
Wang, Yuhao
Su, Shifeng
Liu, Bianjiang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Recent researches have demonstrated that long noncoding RNA linc00152 was aberrantly upregulated in multiple tumor types.
High expression of linc00152 was associated with poor outcomes in cancer patients.
Therefore, we conducted this meta-analysis to evaluate its potential value as a prognostic predictor in various human neoplasms.
Eligible studies were searched through several electronic databases including PubMed, Embase, Web of Science, and the Cochrane Library.
Eight original studies including 752 cancer patients were ultimately enrolled.
Statistical analysis suggested that overexpression of linc00152 was significantly correlated with unfavorable overall survival (OS) (HR = 2.05, 95% CI: 1.59–2.64) and disease-free/progression-free survival (DFS/PFS) (HR = 3.52, 95% CI: 1.82–6.79) in cancer patients.
In addition, a significant correlation was observed between aberrant linc000152 expression and lymph node metastasis (LNM) (OR = 2.49, 95% CI: 1.57–3.94) but not in vessel invasion (VI) (OR = 1.02, 95% CI: 0.54–1.93) and distant metastasis (DM) (OR = 0.600, 95% CI: 0.213–1.689).
Our meta-analysis demonstrated that high linc00152 expression significantly predicted inferior OS and DFS/PFS in multiple neoplasms, as well as advanced LNM and VI.
Linc00152 may serve as a potential indicator in predicting poor outcomes and metastases of diverse cancers.
American Psychological Association (APA)
Miao, Chenkui& Zhao, Kai& Zhu, Jundong& Liang, Chao& Xu, Aiming& Hua, Yibo…[et al.]. 2017. Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137890
Modern Language Association (MLA)
Miao, Chenkui…[et al.]. Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1137890
American Medical Association (AMA)
Miao, Chenkui& Zhao, Kai& Zhu, Jundong& Liang, Chao& Xu, Aiming& Hua, Yibo…[et al.]. Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137890