Resveratrol’s Impact on Vascular Smooth Muscle Cells Hyporeactivity: The Role of Rho-Kinase Inhibition
Joint Authors
Rajewski, Paweł
Malinowski, Bartosz
Wiciński, Michał
Górski, Karol
Walczak, Maciej
Wódkiewicz, Eryk
Słupski, Maciej
Pawlak-Osińska, Katarzyna
Szychta, Paweł
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Resveratrol (3,5,4′-trihydroxystilbene) is a chemical compound belonging to the group of polyphenols and flavonoids.
The aim of the present study was to determine the influence of resveratrol application along with certain modulating factors, such as 8Br-cGMP-activator of cGMP-dependent protein kinases, HA-1077-Rho-kinase inhibitor, and Bay K8644-calcium channel agonist, on VMSCs constriction triggered by phenylephrine.
Resveratrol at a dose of 10 mg/kg/24 h administered for 4 weeks reduced the reactivity of the arteries to the pressure action of catecholamines.
Tests performed after four weeks of resveratrol administration showed that 8Br-cGMP at the concentrations of 0.01 mM/l and 0.1 mM/l intensifies this effect.
Simultaneous resveratrol and Bay K8644 administration led to a significant decrease in contractility compared to the vessels collected from animals (Res−).
This effect was dependent on the concentration of Bay K8644.
Resveratrol seems to be counteractive against Bay K8644 by blocking L-type calcium channels.
As the concentration of HA-1077 increased, there was a marked hyporeactivity of the vessels to the pressure effects of phenylephrine.
The results indicate synergy between resveratrol and Rho-kinase inhibition.
American Psychological Association (APA)
Wiciński, Michał& Malinowski, Bartosz& Rajewski, Paweł& Szychta, Paweł& Wódkiewicz, Eryk& Walczak, Maciej…[et al.]. 2020. Resveratrol’s Impact on Vascular Smooth Muscle Cells Hyporeactivity: The Role of Rho-Kinase Inhibition. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137905
Modern Language Association (MLA)
Wiciński, Michał…[et al.]. Resveratrol’s Impact on Vascular Smooth Muscle Cells Hyporeactivity: The Role of Rho-Kinase Inhibition. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1137905
American Medical Association (AMA)
Wiciński, Michał& Malinowski, Bartosz& Rajewski, Paweł& Szychta, Paweł& Wódkiewicz, Eryk& Walczak, Maciej…[et al.]. Resveratrol’s Impact on Vascular Smooth Muscle Cells Hyporeactivity: The Role of Rho-Kinase Inhibition. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137905