Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits
Joint Authors
Kim, Kee-Deog
Jung, Ui-Won
Park, Wonse
Huh, Jisun
Park, Kyeong-Mee
Kim, Hyun Sil
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
This study evaluated the effect of administering intermittent parathyroid hormone [PTH (1-34), henceforth PTH] on the early-stage bone healing of maxillary sinus augmentation in healthy rabbits.
Materials and Methods.
Bovine bone mineral was grafted on the sinuses of 20 female New Zealand white rabbits.
The animals were randomly divided into two groups, PTH (n=10) or saline (n=10), in which either PTH or saline was injected subcutaneously 5 days a week for 2 weeks.
Half of the animals in each group were killed at 2 weeks postoperatively and the other half were killed at 4 weeks postoperatively.
The dosage of PTH was 10 μg/kg/day.
Radiographic and histomorphometric analyses were performed.
Result.
The new bone area (NBA) did not differ significantly between the PTH and saline groups.
The NBA in the PTH group in the total augmented area and in the demarcated window, center, and Schneiderian membrane regions increased significantly from 2 to 4 weeks.
The number of osteoclasts decreased significantly from 2 to 4 weeks in both groups, with no difference between the two groups.
Conclusion.
Intermittent PTH might not stimulate new bone formation in healthy rabbits during the first 4 weeks of healing.
American Psychological Association (APA)
Huh, Jisun& Jung, Ui-Won& Park, Kyeong-Mee& Kim, Hyun Sil& Kim, Kee-Deog& Park, Wonse. 2017. Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137943
Modern Language Association (MLA)
Huh, Jisun…[et al.]. Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137943
American Medical Association (AMA)
Huh, Jisun& Jung, Ui-Won& Park, Kyeong-Mee& Kim, Hyun Sil& Kim, Kee-Deog& Park, Wonse. Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137943