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Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical Relevance
Joint Authors
Kurtenkov, Oleg
Klaamas, Kersti
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Natural antibodies to the tumor-associated Thomsen-Friedenreich antigen (TF) are related to tumor immunosurveillance and cancer patients’ survival.
Hidden IgG antibodies (HAbs) to TF, their lectin reactivity, avidity, and clinical relevance were studied.
HAbs were present in cancer patients and controls.
A decreased level of IgG HAbs was detected in cancer.
The HAbs level positively correlated with the sialospecific SNA lectin binding in purified total IgG (tIgG) in donors and cancer patients, indicating that HAbs are higher sialylated.
The avidity of anti-TF IgG in tIgG samples was lower in cancer patients (P=0.025) while no difference in the avidity of free anti-TF IgG was established.
A negative correlation between the avidity of anti-TF IgG in tIgG and SNA binding in both groups was observed (P<0.0001).
The HAbs level negatively correlated with the anti-TF IgG avidity in tIgG only in donors (P=0.003).
Changes in the level of HAbs and Abs avidity showed a rather good stage- and gender-dependent diagnostic accuracy.
Cancer patients with a lower anti-TF IgG avidity in tIgG showed a benefit in survival.
Thus the TF-specific HAbs represent a particular subset of anti-TF IgG that differ from free serum anti-TF IgG in SNA reactivity, avidity, diagnostic potential, and relation to survival.
American Psychological Association (APA)
Kurtenkov, Oleg& Klaamas, Kersti. 2017. Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical Relevance. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137949
Modern Language Association (MLA)
Kurtenkov, Oleg& Klaamas, Kersti. Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical Relevance. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1137949
American Medical Association (AMA)
Kurtenkov, Oleg& Klaamas, Kersti. Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical Relevance. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137949