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Identifying and Analyzing Novel Epilepsy-Related Genes Using Random Walk with Restart Algorithm
Joint Authors
Jiang, Yang
Gao, Yu-Fei
Feng, Kaiyan
Wang, ShaoPeng
Guo, Wei
Shang, Dong-Mei
Cao, Jing-Hui
He, Yi-Chun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
As a pathological condition, epilepsy is caused by abnormal neuronal discharge in brain which will temporarily disrupt the cerebral functions.
Epilepsy is a chronic disease which occurs in all ages and would seriously affect patients’ personal lives.
Thus, it is highly required to develop effective medicines or instruments to treat the disease.
Identifying epilepsy-related genes is essential in order to understand and treat the disease because the corresponding proteins encoded by the epilepsy-related genes are candidates of the potential drug targets.
In this study, a pioneering computational workflow was proposed to predict novel epilepsy-related genes using the random walk with restart (RWR) algorithm.
As reported in the literature RWR algorithm often produces a number of false positive genes, and in this study a permutation test and functional association tests were implemented to filter the genes identified by RWR algorithm, which greatly reduce the number of suspected genes and result in only thirty-three novel epilepsy genes.
Finally, these novel genes were analyzed based upon some recently published literatures.
Our findings implicate that all novel genes were closely related to epilepsy.
It is believed that the proposed workflow can also be applied to identify genes related to other diseases and deepen our understanding of the mechanisms of these diseases.
American Psychological Association (APA)
Guo, Wei& Shang, Dong-Mei& Cao, Jing-Hui& Feng, Kaiyan& He, Yi-Chun& Jiang, Yang…[et al.]. 2017. Identifying and Analyzing Novel Epilepsy-Related Genes Using Random Walk with Restart Algorithm. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1137961
Modern Language Association (MLA)
Guo, Wei…[et al.]. Identifying and Analyzing Novel Epilepsy-Related Genes Using Random Walk with Restart Algorithm. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1137961
American Medical Association (AMA)
Guo, Wei& Shang, Dong-Mei& Cao, Jing-Hui& Feng, Kaiyan& He, Yi-Chun& Jiang, Yang…[et al.]. Identifying and Analyzing Novel Epilepsy-Related Genes Using Random Walk with Restart Algorithm. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1137961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137961