Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis
Joint Authors
Jin, Hongting
Xu, Shibing
Zhang, Lei
Shan, Letian
Zhou, Li
Xiao, Luwei
Tong, Peijian
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
This study aims to systematically evaluate the efficacy and safety of core decompression combined transplantation of autologous bone marrow stem cells (CDBMSCs) for treatment of avascular necrosis of the femoral head (ANFH).
Methods.
Randomized controlled trials (RCTs) regarding effectiveness of core decompression combined transplantation of autologous bone marrow stem cells for treating ANFH were searched in 8 comprehensive databases prior to September 2016.
The data analysis was performed by using the RevMan version 5.3.
Results.
A total of 11 studies with 507 participants were included.
Results showed that CDBMSCs group was more effective than CD group in increasing Harris hip score, decreasing necrotic area of femoral head, collapse of femoral head, and conversion to total hip replacement incidence.
In the subgroup analysis, the results did not change in different intervention measure substantially.
In addition, the safety of CDBMSCs for ANFH is reliable.
Conclusion.
Based on the systematic review, our findings suggest that core decompression combined transplantation of autologous bone marrow stem cells appeared to be more efficacious in the treatment at early stages of ANFH.
American Psychological Association (APA)
Xu, Shibing& Zhang, Lei& Jin, Hongting& Shan, Letian& Zhou, Li& Xiao, Luwei…[et al.]. 2017. Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137966
Modern Language Association (MLA)
Xu, Shibing…[et al.]. Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1137966
American Medical Association (AMA)
Xu, Shibing& Zhang, Lei& Jin, Hongting& Shan, Letian& Zhou, Li& Xiao, Luwei…[et al.]. Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137966