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The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-07
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Cellular interaction is inevitable in the pathomechanism of human disease.
Formation of heterotypic cellular aggregates, between distinct cells of hematopoietic and nonhematopoietic origin, may be involved in events leading to inflammation and the complex process of cancer progression.
Among adhesion receptors, the family of selectins with their ligands have been considered as one of the major contributors to cell-cell interactions.
Consequently, the inhibition of the interplay between selectins and their ligands may have potential therapeutic benefits.
In this review, we focus on the current evidence on the selectins as crucial modulators of inflammatory, thrombotic, and malignant disorders.
Knowing that there is promiscuity in selectin binding, we outline the importance of a key protein that serves as a ligand for all selectins.
This dimeric mucin, the P-selectin glycoprotein ligand 1 (PSGL-1), has emerged as a major player in inflammation, thrombus, and cancer development.
We discuss the interaction of PSGL-1 with various selectins in physiological and pathological processes with particular emphasis on mechanisms that lead to severe disease.
American Psychological Association (APA)
Kappelmayer, János& Nagy, Béla. 2017. The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression. BioMed Research International،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1137968
Modern Language Association (MLA)
Kappelmayer, János& Nagy, Béla. The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression. BioMed Research International No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1137968
American Medical Association (AMA)
Kappelmayer, János& Nagy, Béla. The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1137968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137968