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Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk12 Pathways
Joint Authors
Chen, Yanfang
Shui, Xiaorong
Lei, Wei
Lan, Xiaozhong
Huang, Shian
Zhu, Xiulong
Huang, Wenjun
He, Yuan
Pang, Lingpin
Chen, Can
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study aimed to investigate the effects and mechanisms of quercetin on pulmonary arterial endothelial cell (PAEC) transdifferentiation into smooth muscle-like cells.
TGF-β1-induced PAEC transdifferentiation models were applied to evaluate the pharmacological actions of quercetin.
PAEC proliferation was detected with CCK8 method and BurdU immunocytochemistry.
Meanwhile, the identification and transdifferentiation of PAECs were determined by FVIII immunofluorescence staining and α-SMA protein expression.
The related mechanism was elucidated based on the levels of Akt and Erk1/2 signal pathways.
As a result, quercetin effectively inhibited the TGF-β1-induced proliferation and transdifferentiation of the PAECs and activation of Akt/Erk1/2 cascade in the cells.
In conclusion, quercetin is demonstrated to be effective for pulmonary arterial hypertension (PAH) probably by inhibiting endothelial transdifferentiation possibly via modulating Akt and Erk1/2 expressions.
American Psychological Association (APA)
Huang, Shian& Zhu, Xiulong& Huang, Wenjun& He, Yuan& Pang, Lingpin& Lan, Xiaozhong…[et al.]. 2017. Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk12 Pathways. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137973
Modern Language Association (MLA)
Huang, Shian…[et al.]. Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk12 Pathways. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137973
American Medical Association (AMA)
Huang, Shian& Zhu, Xiulong& Huang, Wenjun& He, Yuan& Pang, Lingpin& Lan, Xiaozhong…[et al.]. Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk12 Pathways. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137973