![](/images/graphics-bg.png)
Predicting Venous Thromboembolic Events in Patients with Coronavirus Disease 2019 Requiring Hospitalization: an Observational Retrospective Study by the COVIDIC Initiative in a Swiss University Hospital
Joint Authors
Kampouri, Eleftheria
Filippidis, Paraskevas
Viala, Benjamin
Méan, Marie
Pantet, Olivier
Desgranges, Florian
Tschopp, Jonathan
Regina, Jean
Karachalias, Eleftherios
Bianchi, Christophe
Zermatten, Maxime G.
Qanadli, Salah Dine
Bart, Pierre-Alexandre
Pagani, Jean-Luc
Guery, Benoit
Alberio, Lorenzo
Papadimitriou-Olivgeris, Matthaios
RegCOVID Research Group, Matthaios
Jaton, Katia
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Coronavirus disease 2019 (COVID-19) can result in profound changes in blood coagulation.
The aim of the study was to determine the incidence and predictors of venous thromboembolic events (VTE) among patients with COVID-19 requiring hospital admission.
Subjects and Methods.
We performed a retrospective study at the Lausanne University Hospital with patients admitted because of COVID-19 from February 28 to April 30, 2020.
Results.
Among 443 patients with COVID-19, VTE was diagnosed in 41 patients (9.3%; 27 pulmonary embolisms, 12 deep vein thrombosis, one pulmonary embolism and deep vein thrombosis, one portal vein thrombosis).
VTE was diagnosed already upon admission in 14 (34.1%) patients and 27 (65.9%) during hospital stay (18 in ICU and nine in wards outside the ICU).
Multivariate analysis revealed D-dimer value>3,120 ng/ml (P<0.001; OR 15.8, 95% CI 4.7-52.9) and duration of 8 days or more from COVID-19 symptoms onset to presentation (P 0.020; OR 4.8, 95% CI 1.3-18.3) to be independently associated with VTE upon admission.
D-dimer value≥3,000 ng/l combined with a Wells score for PE≥2 was highly specific (sensitivity 57.1%, specificity 91.6%) in detecting VTE upon admission.
Development of VTE during hospitalization was independently associated with D-dimer value>5,611 ng/ml (P<0.001; OR 6.3, 95% CI 2.4-16.2) and mechanical ventilation (P<0.001; OR 5.9, 95% CI 2.3-15.1).
Conclusions.
VTE seems to be a common COVID-19 complication upon admission and during hospitalization, especially in ICU.
The combination of Wells≥2 score and D−dimer≥3,000 ng/l is a good predictor of VTE at admission.
American Psychological Association (APA)
Kampouri, Eleftheria& Filippidis, Paraskevas& Viala, Benjamin& Méan, Marie& Pantet, Olivier& Desgranges, Florian…[et al.]. 2020. Predicting Venous Thromboembolic Events in Patients with Coronavirus Disease 2019 Requiring Hospitalization: an Observational Retrospective Study by the COVIDIC Initiative in a Swiss University Hospital. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137982
Modern Language Association (MLA)
Kampouri, Eleftheria…[et al.]. Predicting Venous Thromboembolic Events in Patients with Coronavirus Disease 2019 Requiring Hospitalization: an Observational Retrospective Study by the COVIDIC Initiative in a Swiss University Hospital. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1137982
American Medical Association (AMA)
Kampouri, Eleftheria& Filippidis, Paraskevas& Viala, Benjamin& Méan, Marie& Pantet, Olivier& Desgranges, Florian…[et al.]. Predicting Venous Thromboembolic Events in Patients with Coronavirus Disease 2019 Requiring Hospitalization: an Observational Retrospective Study by the COVIDIC Initiative in a Swiss University Hospital. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137982