Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK-CDK5-PPARγ Signaling
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Crocin is a carotenoid compound which possesses multiple biological activities.
Our and other laboratory’s previous findings show that crocin alleviates obesity and type 2 diabetes-related complications.
We have found that crocin activates AMP-activated protein kinase (AMPK) signaling and inhibition of AMPK suppresses crocin-induced protective effects.
However, the causal role of AMPK activation in the biological role of crocin is still not verified.
In the present study, we showed that crocin markedly inhibits the changes of glucose metabolic parameters and serum lipid profiles in wild type diabetic mice.
In AMPKα KO diabetic mice, those protective effects of crocin against glucose and lipid metabolic dysfunction were abolished.
These results demonstrated AMPK activation was responsible for the beneficial effects of crocin on metabolic dysfunction.
Moreover, we have shown that the antiobese effect of crocin has been abolished by the deficiency of AMPKα.
We also showed that crocin induced a significant decrease of CDK5 protein level in wild type diabetic mice, while this effect was abolished in AMPKα KO diabetic mice.
The regulation of downstream targets of CDK5/PPARγ by crocin was abolished by the deficiency of AMPK.
In conclusion, our study verified that activation of AMPK is involved in crocin-induced protective effects against glucose and lipid metabolic dysfunction.
Activation of AMPK downregulates the protein level of CDK5, followed by the decrease of PPARγ phosphorylation, leading to the inhibition of adipose formation and metabolic dysfunction.
Our study provides new insights into the mechanism of protective effects of crocin and interaction of AMPK and CDK5/PPARγ signaling.
American Psychological Association (APA)
Fang, Kai& Gu, Ming. 2020. Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK-CDK5-PPARγ Signaling. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137987
Modern Language Association (MLA)
Fang, Kai& Gu, Ming. Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK-CDK5-PPARγ Signaling. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1137987
American Medical Association (AMA)
Fang, Kai& Gu, Ming. Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK-CDK5-PPARγ Signaling. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137987