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Circulating Exosomal SOCS2-AS1 Acts as a Novel Biomarker in Predicting the Diagnosis of Coronary Artery Disease
Joint Authors
Liang, Caihong
Zhang, Lulu
Lian, Xiaoqing
Zhu, Tiantian
Zhang, Yuqing
Gu, Ning
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Aims.
Critical roles of circulating exosomal long noncoding RNAs (lncRNAs) have been implicated in multiple diseases.
However, little is known about their roles in coronary artery disease (CAD).
The aim of the present study was to investigate the relationships between circulating exosomal lncRNAs and CAD and identify the aberrantly expressed disease-related lncRNAs as biomarkers in diagnosing CAD.
Methods.
The aberrantly expressed lncRNAs in plasma exosomes from CAD patients and controls were identified by microarray analysis and verified by quantitative real-time PCR (qRT-PCR).
Then, the correlation between the expression level of candidate biomarker and clinic features in CAD patients, mild coronary artery stenosis (mCAS) patients, and controls was analyzed.
Finally, we used the receiver operating characteristic (ROC) curve to examine the diagnosis value of candidate biomarkers.
Results.
The downregulated SOCS2-AS1 was determined by microarray analysis and verified by qRT-PCR in plasma from CAD patients in contrast to controls.
The SOCS2-AS1 expression level in plasma exosomes was negatively correlated with PLT and Lpa.
Moreover, CAD patients with elevated levels of plasma exosome-encapsulated SOCS2-AS1 were susceptible to multicoronary artery lesions.
Additionally, the area under ROC (AUC) of SOCS2-AS1 was 0.704 (95% CI = 0.607–0.801, P<0.001) for diagnosis of CAD.
Conclusions.
Plasma exosome-encapsulated SOCS2-AS1 was an independent protective factor against CAD and could be potentially used as a novel biomarker for the diagnosis of CAD.
American Psychological Association (APA)
Liang, Caihong& Zhang, Lulu& Lian, Xiaoqing& Zhu, Tiantian& Zhang, Yuqing& Gu, Ning. 2020. Circulating Exosomal SOCS2-AS1 Acts as a Novel Biomarker in Predicting the Diagnosis of Coronary Artery Disease. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138005
Modern Language Association (MLA)
Liang, Caihong…[et al.]. Circulating Exosomal SOCS2-AS1 Acts as a Novel Biomarker in Predicting the Diagnosis of Coronary Artery Disease. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138005
American Medical Association (AMA)
Liang, Caihong& Zhang, Lulu& Lian, Xiaoqing& Zhu, Tiantian& Zhang, Yuqing& Gu, Ning. Circulating Exosomal SOCS2-AS1 Acts as a Novel Biomarker in Predicting the Diagnosis of Coronary Artery Disease. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138005