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Contribution of Inhibitor of DNA BindingDifferentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease
Joint Authors
Doke, Mayur
Avecilla, Vincent
Felty, Quentin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-13
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
The overwhelming increase in the global incidence of obesity and its associated complications such as insulin resistance, atherosclerosis, pulmonary disease, and degenerative disorders including dementia constitutes a serious public health problem.
The Inhibitor of DNA Binding/Differentiation-3 (ID3), a member of the ID family of transcriptional regulators, has been shown to play a role in adipogenesis and therefore ID3 may influence obesity and metabolic health in response to environmental factors.
This review will highlight the current understanding of how ID3 may contribute to complex chronic diseases via metabolic perturbations.
Based on the increasing number of reports that suggest chronic exposure to and accumulation of endocrine disrupting chemicals (EDCs) within the human body are associated with metabolic disorders, we will also consider the impact of these chemicals on ID3.
Improved understanding of the ID3 pathways by which exposure to EDCs can potentiate complex chronic diseases in populations with metabolic disorders (obesity, metabolic syndrome, and glucose intolerance) will likely provide useful knowledge in the prevention and control of complex chronic diseases associated with exposure to environmental pollutants.
American Psychological Association (APA)
Avecilla, Vincent& Doke, Mayur& Felty, Quentin. 2017. Contribution of Inhibitor of DNA BindingDifferentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease. BioMed Research International،Vol. 2017, no. 2017, pp.1-22.
https://search.emarefa.net/detail/BIM-1138034
Modern Language Association (MLA)
Avecilla, Vincent…[et al.]. Contribution of Inhibitor of DNA BindingDifferentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease. BioMed Research International No. 2017 (2017), pp.1-22.
https://search.emarefa.net/detail/BIM-1138034
American Medical Association (AMA)
Avecilla, Vincent& Doke, Mayur& Felty, Quentin. Contribution of Inhibitor of DNA BindingDifferentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-22.
https://search.emarefa.net/detail/BIM-1138034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138034