Identification of F5 as a Prognostic Biomarker in Patients with Gastric Cancer
Joint Authors
Liao, Xiwen
Luo, Shan-Shan
Liu, Yi
Qin, Yu-Zhou
Mo, Xian-Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Association of Coagulation factor V (F5) polymorphisms with the occurrence of many types of cancers has been widely reported, but whether it is of prognostic relevance in some cancers remain to be resolved.
The RNA-sequencing dataset was downloaded from The Cancer Genome Atlas (TCGA).
The potential of F5 genes to predict the survival time of gastric cancer (GC) patients was investigated using univariate and multivariate survival analysis whereas “Kaplan-Meier plotter” (KM-plotter) online tools were employed to validate the outcomes.
TCGA data revealed that F5 mRNA levels were significantly upregulated in gastric cancer samples.
Survival analysis confirmed that high levels of F5 mRNA correlated with short overall survival (OS) in gastric cancer patients, and the area under the curve (AUC) values of 1-, 2-, and 5-year OS rate were 0.554, 0.593, and 0.603, respectively.
Survival analysis by KM-plotter indicated that the high expression of F5 mRNA was significantly associated with a shorter OS compared with the low expression level in all patients with GC, and this was also the case for patients in stage III (hazard ratio HR=1.78, P=0.017).
These findings suggest that the F5 gene is significantly upregulated in GC tumour tissues, and may be a potential prognostic biomarker for GC.
American Psychological Association (APA)
Liu, Yi& Liao, Xiwen& Qin, Yu-Zhou& Mo, Xian-Wei& Luo, Shan-Shan. 2020. Identification of F5 as a Prognostic Biomarker in Patients with Gastric Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1138051
Modern Language Association (MLA)
Liu, Yi…[et al.]. Identification of F5 as a Prognostic Biomarker in Patients with Gastric Cancer. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1138051
American Medical Association (AMA)
Liu, Yi& Liao, Xiwen& Qin, Yu-Zhou& Mo, Xian-Wei& Luo, Shan-Shan. Identification of F5 as a Prognostic Biomarker in Patients with Gastric Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1138051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138051