Analyzing Active Constituents and Optimal Steaming Conditions Related to the Hematopoietic Effect of Steamed Panax notoginseng by Network Pharmacology Coupled with Response Surface Methodology
Joint Authors
Zhou, Shuhan
Jiang, Nan
Zhang, Min
Xiao, Xiao
Liu, Zhiyi
Xu, Xiaohui
Gao, Qinghua
Lv, Wenliang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
During hundreds of years of medication, it is believed that the steamed Panax notoginseng (SPN) can enrich and regulate the blood, replenish the body, and improve the health.
The aim of this study was to optimize the steaming conditions of SPN which are related to the hematopoietic effect.
In the study, network pharmacology and pharmacological experiments were used to predict and verify the potential hematopoietic active ingredients of SPN.
Three variables including the steaming time (2-10 h), steaming temperature (90-130°C), and different producing areas of PN were investigated by using single-factor analysis.
Box-Behnken design response surface methodology (BBD-RSM) was performed to explore the optimized steaming conditions which are responsible for the hematopoietic effect of SPN.
Furthermore, the hematopoietic effect of the optimized SPN was evaluated.
Results demonstrated that ginsenoside Rd, Rh1, Rh4, Rk3, and 20(S)-Rg3 can significantly increase blood routine parameters and expressions of hematopoietic factors in anemia mice.
The total contents of the five ginsenosides were selected as evaluation indexes of the response surface method.
We found that the PN from Wenshan steamed at 120°C for 5 h could significantly increase the levels of blood routine parameters and hematopoietic factor expression compared with the model group.
The study not only provides data support for the determination of hematinic effect-related markers for SPN but also gives a scientific reference for the processing of SPN which has a better hematopoietic effect.
The underlying mechanisms require further research.
American Psychological Association (APA)
Zhou, Shuhan& Jiang, Nan& Zhang, Min& Xiao, Xiao& Liu, Zhiyi& Xu, Xiaohui…[et al.]. 2020. Analyzing Active Constituents and Optimal Steaming Conditions Related to the Hematopoietic Effect of Steamed Panax notoginseng by Network Pharmacology Coupled with Response Surface Methodology. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1138088
Modern Language Association (MLA)
Zhou, Shuhan…[et al.]. Analyzing Active Constituents and Optimal Steaming Conditions Related to the Hematopoietic Effect of Steamed Panax notoginseng by Network Pharmacology Coupled with Response Surface Methodology. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1138088
American Medical Association (AMA)
Zhou, Shuhan& Jiang, Nan& Zhang, Min& Xiao, Xiao& Liu, Zhiyi& Xu, Xiaohui…[et al.]. Analyzing Active Constituents and Optimal Steaming Conditions Related to the Hematopoietic Effect of Steamed Panax notoginseng by Network Pharmacology Coupled with Response Surface Methodology. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1138088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138088