Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection
Joint Authors
He, Xiaobing
Cheng, Wen-Yu
Jia, Huai-Jie
Chen, Guo-Hua
Feng, Yuan
Wang, Chun-Yan
Wang, Xiao-Xia
Jing, Zhizhong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Ectromelia virus (ECTV), the causative agent of mousepox, has emerged as a valuable model for investigating the host-Orthopoxvirus relationship as it relates to pathogenesis and the immune response.
ECTV is a mouse-specific virus and causes high mortality in susceptible mice strains, including BALB/c and C3H, whereas C57BL/6 and 129 strains are resistant to the disease.
To understand the host genetic factors in different mouse strains during the ECTV infection, we carried out a microarray analysis of spleen tissues derived from BALB/c and C57BL/6 mice, respectively, at 3 and 10 days after ECTV infection.
Differential Expression of Genes (DEGs) analyses revealed distinct differences in the gene profiles of susceptible and resistant mice.
The susceptible BALB/c mice generated more DEGs than the resistant C57BL/6 mice.
Additionally, gene ontology and KEGG pathway analysis showed the DEGs of susceptible mice were involved in innate immunity, apoptosis, metabolism, and cancer-related pathways, while the DEGs of resistant mice were largely involved in MAPK signaling and leukocyte transendothelial migration.
Furthermore, the BALB/c mice showed a strong induction of interferon-induced genes, which, however, were weaker in the C57BL/6 mice.
Collectively, the differential transcriptome profiles of susceptible and resistant mouse strains with ECTV infection will be crucial for further uncovering the molecular mechanisms of the host-Orthopoxvirus interaction.
American Psychological Association (APA)
Cheng, Wen-Yu& Jia, Huai-Jie& He, Xiaobing& Chen, Guo-Hua& Feng, Yuan& Wang, Chun-Yan…[et al.]. 2017. Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138100
Modern Language Association (MLA)
Cheng, Wen-Yu…[et al.]. Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1138100
American Medical Association (AMA)
Cheng, Wen-Yu& Jia, Huai-Jie& He, Xiaobing& Chen, Guo-Hua& Feng, Yuan& Wang, Chun-Yan…[et al.]. Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138100